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Effects of maternal feeding of clofibrate on hepatic fatty acid metabolism in suckling piglet.
J Anim Sci Biotechnol
December 2024
Laboratory of Developmental Nutrition, Department of Animal Science, North Carolina State University, Raleigh, NC, 27695, USA.
Background: Energy deficiency is a leading cause of the high pre-weaning mortality of neonatal piglets in the swine industry. Thus, optimal energy metabolism is of crucial importance for improving the survivability of neonatal piglets. The effective utilization of milk fat as primary energy is indispensably required.
View Article and Find Full Text PDFThe effect of aging on the repeated-dose liver micronucleus assay using N-nitrosodipropylamine, quinoline, and carbendazim.
Mutat Res Genet Toxicol Environ Mutagen
October 2024
Tokyo Laboratory, BoZo Research Center Inc., 1-3-11 Hanegi, Setagaya-ku, Tokyo 156-0042, Japan. Electronic address:
The repeated dose liver micronucleus (RDLMN) assay has been sufficiently validated in terms of the numbers and types of chemicals studied. However, it remains unclear whether aging affects assay results. The OECD Test Guideline 407 (Repeated Dose 28-Day Oral Toxicity Study in Rodents) indicates that dosing should begin as soon as feasible after weaning and in any event before 9 weeks of age.
View Article and Find Full Text PDFEffects of species of origin and mode of induction of microsomes on carbamazepine-induced cell toxicity.
J Pharmacol Toxicol Methods
July 2024
Department of Paediatrics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada; Robarts Research Institute, University of Western Ontario, London, Ontario, Canada.
Article Synopsis
- Standardization and validation of in vitro drug metabolism are crucial for drug development and toxicity testing, particularly in assays like the lymphocyte toxicity assay (LTA) and in vitro platelet toxicity assay (iPTA).
- The study focused on how the species of origin and different induction agents affect the metabolic capacities of isolated liver microsomes (MICs) when bioactivating carbamazepine (CBZ), with cytotoxicity as a key measure.
- Results showed that MICs from minipigs and rat MICs conditioned with 3-methylcholanthrene (3MC) produced the most cytotoxic metabolites, offering insights to improve in vitro toxicity assays and guiding pre-clinical drug investigations.
The Effect of Clofibrate and Phototherapy on Prolonged Jaundice due to Breast Milk in Full-Term Neonates.
Clin Med Insights Pediatr
June 2023
Department of Pediatrics, Hamadan University of Medical Sciences, Hamadan, Iran.
Introduction: Jaundice is one of the most common problems during infancy. It is believed that breast milk jaundice is one of the reasons for the persistence of jaundice after 14 days of prolonged jaundice. This study evaluates the effect of Clofibrate and phototherapy on prolonged jaundice originating from breast milk in term and healthy neonates.
View Article and Find Full Text PDFEvaluation of mRNA markers in differentiating human SH-SY5Y cells for estimation of developmental neurotoxicity.
Neurotoxicology
July 2023
Department of Biochemistry and Biophysics, Stockholm University, 106 91 Stockholm, Sweden. Electronic address:
Current guidelines for developmental neurotoxicity (DNT) evaluation are based on animal models. These have limitations so more relevant, efficient and robust approaches for DNT assessment are needed. We have used the human SH-SY5Y neuroblastoma cell model to evaluate a panel of 93 mRNA markers that are frequent in Neuronal diseases and functional annotations and also differentially expressed during retinoic acid-induced differentiation in the cell model.
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