AI Article Synopsis
- The study examined the impact of increased animal protein intake on urinary factors related to stone formation in six normal male subjects.
- Increased dietary animal protein by 34 g/day led to significant rises in urinary calcium (23%) and oxalate (24%), along with a notable increase in total urinary nitrogen.
- The overall risk of stone formation rose dramatically, estimated at 250% during the high animal protein intake period.
Article Abstract
1. Studies were carried out on six normal male subjects to determine the short-term effect of increasing the dietary consumption of animal protein on the urinary risk factors for stone-formation, namely, volume, pH, calcium oxalate, uric acid and glycosaminoglycans. 2. An increase of 34 g/day of animal protein in the diet significantly increased urinary calcium (23%) and oxalate (24%). Total urinary nitrogen increased by an average of 368 mmol/day. The accompanying increase in dietary purine (11 mmol of purine nitrogen/day) caused a 48% increase in the excretion of uric acid. 3. The overall relative probability of forming stones, calculated from a combination of the risk factors, was markedly increased (250%) throughout the period of high animal protein ingestion.
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| http://dx.doi.org/10.1042/cs0570285 | DOI Listing |
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