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Integrated Analysis of Gut Microbiota and Metabolites in a Rat Necrotizing Enterocolitis Model.
Turk J Gastroenterol
January 2025
Department of Pediatrics, Jinhua Maternal and Child Health Care Hospital, Zhejiang , China.
Human breast milk-derived exosomes and their positive role on neonatal intestinal health.
Pediatr Res
January 2025
Department of Pediatrics, Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, 510623, China.
Although the role of breast milk in promoting neonatal growth and maintaining intestinal homeostasis is well established, underlying mechanisms by which it protects the intestine from damage remain to be elucidated. Human breast milk-derived exosomes (HMDEs) are newly discovered active signaling vesicles with a diameter of 30-150 nm, which are key carriers of biological information exchange between mother and child. In addition, due to their ability to cross the gastrointestinal barrier, low immunogenicity, good biocompatibility and stability, HMDEs play an important role in regulating intestinal barrier integrity in newborns.
View Article and Find Full Text PDFClinical value of quantitative echocardiographic features in preterm infants with necrotizing enterocolitis.
Sci Rep
January 2025
Department of Neonatology, Children's Hospital of Soochow University, Suzhou, China.
This study investigated the correlation between quantitative echocardiographic characteristics within 3 days of birth and necrotizing enterocolitis (NEC) and its severity in preterm infants. A retrospective study was conducted on 168 preterm infants with a gestational age of < 34 weeks. Patients were categorized into NEC and non-NEC groups.
View Article and Find Full Text PDFL-Citrulline in Neonates: From Bench to Bed Side.
Children (Basel)
December 2024
Division of Neonatology, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada.
L-citrulline (L-CIT), a precursor to L-arginine (L-ARG), is a key contributor to the nitric oxide (NO) signaling pathway. Endothelial dysfunction, characterized by deficient nitric oxide synthesis, is implicated in the pathogenesis of various neonatal conditions such as necrotizing enterocolitis (NEC) and bronchopulmonary dysplasia (BPD) associated pulmonary hypertension (PH). This review summarizes the current evidence around the possible role of L-CIT supplementation in the treatment of these conditions.
View Article and Find Full Text PDFGenomic interrogation of commercial infant probiotic products for label accuracy.
Pediatr Res
January 2025
Department of Pediatrics, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Objective: To evaluate the label accuracy of commercial infant probiotic products and identify potential microbial contamination.
Methods: DNA was extracted from seventeen infant probiotic products purchased from a large online vendor. Samples underwent 16S ribosomal RNA gene sequencing, QIIME analysis, and bacterial taxonomic classification.
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