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The effect of on nickel-induced embryotoxicity and cardiotoxicity in rats.
Int J Immunopathol Pharmacol
October 2024
Department of Veterinary Pathology, Babol-Branch, Islamic Azad University, Babol, Iran.
Article Synopsis
- Nickel (Ni) is a heavy metal linked to embryo and heart toxicity, with significant risks for cardiovascular damage, particularly during pregnancy.
- Geraniol (GER) has various health benefits, including antioxidant and cardioprotective effects, prompting investigation into its protective role against Ni toxicity in a rat study.
- Results showed that GER helped reduce fetal skeleton issues and cardiac injury markers in rats exposed to Ni, indicating its potential as a therapeutic agent to mitigate the harmful effects of Ni exposure.
Hazardous effects of nickel ferrite nanoparticles and nickel chloride in early life stages of the freshwater snail Biomphalaria glabrata (Say, 1818).
Environ Sci Pollut Res Int
October 2024
Laboratory of Environmental Biotechnology and Ecotoxicology, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Rua 235, Setor Universitário, Goiânia, Goiás, CEP: 74605050, Brazil.
Article Synopsis
- * A study assessed the toxicity of NiF NPs and nickel chloride on the embryos and newly hatched snails of the species Biomphalaria glabrata over specific exposure periods.
- * Findings revealed that NiF NPs caused higher mortality, developmental delays, lower hatching rates, and morphological changes in embryos compared to newly hatched snails, indicating a significant risk to early developmental stages in freshwater ecosystems.
Nickel nanoparticles affect the migration and invasion of HTR-8/SVneo cells by downregulating MMP2 through the PI3K/AKT pathway.
Toxicol In Vitro
April 2022
School of Public Health, Zunyi Medical University, Zunyi, 563000, Guizhou, China. Electronic address:
Proper migration and invasion of extravillous trophoblast cells into the endometrium in early gestation is essential for successful embryo implantation. The development of nanotechnology has led to the emergence of nickel nanoparticles (Ni NPs), for which attendant health concerns are widespread. Ni NPs are known to affect reproduction and be embryotoxic, but whether they affect the migration and invasion functions of trophoblast cells is unclear.
View Article and Find Full Text PDFZebrafish embryos as a screen for DNA methylation modifications after compound exposure.
Toxicol Appl Pharmacol
January 2016
Center for Health Protection, National Institute for Public Health and the Environment (RIVM), PO Box 1, 3720 BA Bilthoven, The Netherlands. Electronic address:
Modified epigenetic programming early in life is proposed to underlie the development of an adverse adult phenotype, known as the Developmental Origins of Health and Disease (DOHaD) concept. Several environmental contaminants have been implicated as modifying factors of the developing epigenome. This underlines the need to investigate this newly recognized toxicological risk and systematically screen for the epigenome modifying potential of compounds.
View Article and Find Full Text PDFCharacterization of synergistic embryotoxicity of nickel and buprofezin in zebrafish.
Environ Sci Technol
April 2015
College of Environment and Resource, Research Center of Environment and Health, Shanxi University, Taiyuan, Shanxi 030006, PR China.
Multiple pollutants, usually at low levels, coexist and may interact in the environment. It is therefore important to analyze the toxicity of mixtures of coexisting chemicals to evaluate the potential ecological risk. Concern regarding the co-occurrence and combined bioeffects of heavy metals and organic insecticides in aquatic settings has existed for many years, but a clear understanding of the interactions between and potential combined toxicity of these chemicals remains elusive.
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