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End-to-End Crystal Structure Prediction from Powder X-Ray Diffraction.
Adv Sci (Weinh)
January 2025
DP Technology, Beijing, 100080, China.
Powder X-ray diffraction (PXRD) is a prevalent technique in materials characterization. While the analysis of PXRD often requires extensive human manual intervention, and most automated method only achieved at coarse-grained level. The more difficult and important task of fine-grained crystal structure prediction from PXRD remains unaddressed.
View Article and Find Full Text PDFReversal of neuronal tau pathology via adiponectin receptor activation.
Commun Biol
January 2025
Division of Geriatrics, Department of Medicine, SMPH, University of Wisconsin-Madison, Madison, WI, USA.
Changes in brain mitochondrial metabolism are coincident with functional decline; however, direct links between the two have not been established. Here, we show that mitochondrial targeting via the adiponectin receptor activator AdipoRon (AR) clears neurofibrillary tangles (NFTs) and rescues neuronal tauopathy-associated defects. AR reduced levels of phospho-tau and lowered NFT burden by a mechanism involving the energy-sensing kinase AMPK and the growth-sensing kinase GSK3b.
View Article and Find Full Text PDFFunctional fitness and psychological well-being in older adults.
BMC Geriatr
January 2025
Institute of Health Promotion and Sport Sciences, Faculty of Education and Psychology, ELTE Eötvös Loránd University, Bogdánfy St. 12, Budapest, H-1117, Hungary.
Background: Physical fitness and functioning are related to better mental health in older age. However, which fitness components (body composition, strength, flexibility, coordination, and endurance) are more closely related to psychological well-being (PWB) is unclear.
Methods: This research examined how body mass index (BMI) and six indices of functional fitness (i.
The well-being of polish general practitioners during the COVID-19 pandemic-cross-sectional questionnaire-based study.
BMC Prim Care
January 2025
Department of Family Medicine, Jagiellonian University Medical College, Kraków, 31-061, Poland.
Background: The COVID-19 pandemic has caused psychological distress to the population and healthcare workers. Physicians' well-being is essential and contributes significantly to overall health. This study aimed to assess the strain on Polish general practitioners from the effects of the COVID-19 pandemic and to ascertain the potential predictors of their distress.
View Article and Find Full Text PDFQuality indicators and development targets in the national clinical quality registries in cancer care and screening.
BMJ Open Qual
January 2025
Danish Center for Health Services Research, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
Background: The Danish clinical quality registries monitor and improve the quality of care, using quality indicators and defined development targets referred to as 'standards'. This study aims to investigate the fulfilment of standards in the Danish clinical quality registries in cancer care and screening.
Methods: Data was included from annual reports in the 27 Danish clinical quality registries in cancer care and screening.
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