A specific radioimmunoassay for the determination of picogram quantities of triamcinolone in plasma is reported. A rapid chemical separation method was incorporated in the procedure to remove the interfering endogenous hydrocortisone which cross reacts (5%) with the antiserum. Application of this radioimmunoassay to the analysis of triamcinolone plasma concentrations following oral administration of a 5 mg dose of the drug to a human volunteer is described.
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