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KIF9 Ameliorates Neuropathology and Cognitive Dysfunction by Promoting Macroautophagy in a Mouse Model of Alzheimer's Disease.
Aging Cell
January 2025
Growth, Development, and Mental Health of Children and Adolescence Center, Pediatric Research Institute, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.
Alzheimer's disease (AD) is a prevalent neurodegenerative disorder affecting the elderly. The imbalance of protein production and degradation processes leads to the accumulation of misfolded and abnormally aggregated amyloid-beta (Aβ) in the extracellular space and forms senile plaques, which constitute one of the most critical pathological hallmarks of AD. KIF9, a member of the kinesin protein superfamily, mediates the anterograde transport of intracellular cargo along microtubules.
View Article and Find Full Text PDFExploring the role of moxibustion robots in teaching: a cross-sectional study.
BMC Med Educ
January 2025
School of Acupuncture and Tuina, Chengdu University of TCM, Chengdu, China.
Background: Artificial intelligence has gradually been used into various fields of medical education at present. Under the background of moxibustion robot teaching assistance, the study aims to explore the relationship and the internal mechanism between learning engagement and evaluation in three stages, preparation before class, participation in class, and consolidation after class.
Methods: Based on the data investigated in 250 youths in university via multistage cluster sampling following the self-administered questionnaire, structural equation model was built to discussing factors of study process about moxibustion robots.
Aim: Study the effectiveness of Cytoflavin in the medical rehabilitation of elderly and senile patients after pneumonia associated with a new coronavirus infection (COVID-19) at the outpatient stage.
Materials And Methods: A prospective observational randomized study involving 66 patients (45 women and 21 men, average age 66.5±5.
The Features of Beta-Amyloid Phosphorylation in Alzheimer's Disease.
Acta Naturae
January 2024
Skolkovo Institute of Science and Technology, Moscow, 121205 Russian Federation.
Article Synopsis
- Accumulation of beta-amyloid peptides (Aβ) and their modifications, particularly phosphorylated serine-8 (pSer8-Aβ), are key factors in the progression of Alzheimer's disease (AD), influencing neuronal degradation and cytotoxicity.* -
- The study found that pSer8-Aβ levels in the brains of 5xFAD mice steadily increase from 3 months to 14-17 months, paralleling the general accumulation of Aβ peptides, and that pSer8-Aβ constitutes up to 1-10% of total Aβ in the cerebrospinal fluid of AD patients.* -
- Mass spectrometry confirmed the possibility of specific Aβ phosphorylation in brain tissues, suggesting
Correlation between serum ANGPTL4 levels and white matter hyperintensity and cognitive impairment in patients with cerebral small vessel disease.
Brain Behav
February 2024
Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Objectives: To investigate the correlation between serum angiopoietin-like protein 4 (ANGPTL4) levels, white matter hyperintensity (WMH), and cognitive impairment (CI) in patients with cerebral small vessel disease (CSVD).
Methods: This cross-sectional study enrolled 171 patients with CSVD who attended the First Affiliated Hospital of Xinxiang Medical University from December 2021 to July 2022. All subjects underwent a 3.
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