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Factors associated with activated clotting time following heparin administration in pediatric cardiopulmonary bypass: A retrospective study.
Perfusion
January 2025
Department of Cardiac Surgery, The University of Tokyo Hospital, Tokyo, Japan.
Introduction: The recently recommended activated clotting time (ACT) to be maintained at the initiation of and during cardiopulmonary bypass (CPB) is ≥480 s. However, the post-unfractionated heparin (UFH) administration ACT occasionally does not exceed 480 s. Therefore, in this study, we retrospectively evaluated the factors influencing post-heparin administration ACT before initiating CPB.
View Article and Find Full Text PDFDevelopment of a hamster model of spontaneous hypertriglyceridemia in diabetes.
Animal Model Exp Med
December 2024
Institute of Cardiovascular Sciences, Peking University Health Science Center, Beijing, China.
Hypertriglyceridemia (HTG) often accompanies diabetes and is considered a risk factor for diabetic vascular complications. However, inducing diabetic HTG typically requires high-fat diets in certain animal models. Leveraging our newly developed LDL receptor knockout hamster model, which exhibits features akin to human lipid metabolism, we sought to determine whether these animals would develop HTG without dietary manipulations in diabetes.
View Article and Find Full Text PDFQuantification of lipoprotein lipase in mouse plasma with a sandwich enzyme-linked immunosorbent assay.
J Lipid Res
April 2024
Department of Clinical Laboratory Medicine, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan; Clinical Laboratory Center, Gunma University Hospital, Maebashi, Gunma, Japan.
To support in vivo and in vitro studies of intravascular triglyceride metabolism in mice, we created rat monoclonal antibodies (mAbs) against mouse LPL. Two mAbs, mAbs 23A1 and 31A5, were used to develop a sandwich ELISA for mouse LPL. The detection of mouse LPL by the ELISA was linear in concentrations ranging from 0.
View Article and Find Full Text PDFSignificant but partial lipoprotein lipase functional loss caused by a novel occurrence of rare LPL biallelic variants.
Lipids Health Dis
April 2024
Department of Critical Care Medicine, Nanjing Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Background: Lipoprotein lipase (LPL) plays a crucial role in triglyceride hydrolysis. Rare biallelic variants in the LPL gene leading to complete or near-complete loss of function cause autosomal recessive familial chylomicronemia syndrome. However, rare biallelic LPL variants resulting in significant but partial loss of function are rarely documented.
View Article and Find Full Text PDFAAV-mediated hepatic LPL expression ameliorates severe hypertriglyceridemia and acute pancreatitis in Gpihbp1 deficient mice and rats.
Mol Ther
January 2024
Department of Critical Care Medicine, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, China. Electronic address:
Article Synopsis
- GPIHBP1 is crucial for breaking down triglyceride lipoproteins but isn't responsible for hypertriglyceridemia in suckling mice; this issue appears after weaning.
- By delivering LPL genes to the liver via AAV, researchers found that increased LPL expression significantly reduces triglycerides and the risk of pancreatitis in Gpihbp1-deficient mice.
- This study suggests that focusing on liver-targeted LPL expression could offer new treatment options for hypertriglyceridemia and its complications linked to GPIHBP1 deficiency.
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