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In Vitro-In Vivo Correlation Of Amorphous Solid Dispersion Enabled Itraconazole Tablets.
Pharm Res
March 2025
Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, 20 Penn Street, Room 623, HSF2 Building, Baltimore, MD, 21201, USA.
Purpose: There are scarce reports on in vitro-in vivo correlation (IVIVC) model development of immediate-release (IR) formulations, and few investigations of the impacts of formulation and process of spray-dried solid dispersions (SDD)-based tablets on human pharmacokinetics (PK), despite commercial product successes. The goal of this study was to investigate the formulation and process factors that impact bioavailability enhancement of IR itraconazole SDD tablets; and to develop an FDA level A IVIVC that would predict in vivo PK performance from in vitro dissolution testing.
Methods: A direct, differential-equation-based IVIVC model approach was employed, using an oral solution for post-dissolution disposition and Fast-, Medium-, and Slow-release tablets.
Synergistic Construction of Electrode-Electrolyte Interphases via Electrolyte Cosolvent and Additive Chemistry toward Ultrastable and Fast-Charging Li-Rich Batteries.
ACS Appl Mater Interfaces
March 2025
State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
Lithium-rich manganese oxide (LRMO) is a promising high-energy-density material for high-voltage lithium-ion batteries, but its performance is hindered by interfacial side reactions, transition metal dissolution, and oxygen release. To address these issues, we propose a high-voltage electrolyte strategy that utilizes cosolvent and additive synergy to create stable dual interphases at both the cathode and anode. Specifically, lithium difluoro(oxalato)borate (LiDFOB) additive sacrificially decomposes to form a uniform yet stable cathode-electrolyte interphase (CEI) layer, while cosolvent of bis(2,2,2-trifluoroethyl) carbonate (BTFEC) effectively adjusts the solvation structure and synergistically stabilizes the solid-electrolyte interphase (SEI) on the anode, ultimately achieving ultrahigh cycle stability and fast-charging feasibility.
View Article and Find Full Text PDFFabricating stable protective layer on orthorhombic tungsten oxide anode for long-lifespan pseudocapacitors by trace of aluminum ion electrolyte additives.
J Colloid Interface Sci
March 2025
School of Metallurgy, Northeastern University, Shenyang 110819, China.
Orthorhombic tungsten oxide (WO·HO) has been considered as a promising anode material due to its layered crystal structure and high capacity. However, the instability of its crystal structure usually results in poor cyclic stability of the battery/capacitor. Herein, a novel strategy of introducing aluminum ion (Al) additives for designing hybrid electrolyte is demonstrated to enhance the cycling stability of WO·HO.
View Article and Find Full Text PDFInfluence of chitin purity on its dissolution behaviour in alkaline solvent.
Carbohydr Polym
May 2025
Centre for Aquaculture and Seafood Development, Marine Institute, Memorial University of Newfoundland and Labrador, 155 Ridge Road, St. John's, NL A1C 5R3, Canada. Electronic address:
The biopolymer chitin is a promising ingredient for bioplastics due to its strength and stability. Chitin fibres must be isolated from biomass by stripping away tightly bound minerals, proteins, and pigments. Depending on the desired chitin purity, this isolation process can be long and cost-prohibitive on industrial scale.
View Article and Find Full Text PDFClinical Translation of Hyperpolarized C Metabolic Probes for Glioma Imaging.
AJNR Am J Neuroradiol
March 2025
From the Department of Radiology and Biomedical Imaging (A.W.A., Y.K., D.D., H.C., J.B.S., R.A.B., D.X., J.M.L., J.W.G., P.E.Z.L., D.B.V., Y.L.), Department of Neurological Surgery (D.B.V., S.M.C.), Department of Bioengineering and Therapeutic Sciences (D.B.V.) University of California San Francisco, San Francisco, CA, USA.
Hyperpolarized carbon-13 (HP-C) MRI enables the real-time measurement of dynamic metabolism by utilizing molecular probes whose magnetization has been transiently enhanced via dynamic nuclear polarization of C labels. Based on pre-clinical and clinical investigations demonstrating Warburg-related metabolic dysfunction and tricarboxylic acid (TCA)-cycle alterations in gliomas, HPC techniques appear very promising for overcoming conventional challenges to evaluating tumor burden and extent, early therapeutic response and progression among patients non-invasively. This article surveys the multi-faceted translational development of HP-C MRI in the context of glioma imaging, while emphasizing innovation concerning the pharmacy production of HP probes - [1-C]/[2-C]-pyruvate and [1-C,5-C]-alpha-ketoglutarate - that serve as non-radioactive metabolic contrast agents.
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