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Serotonin Syndrome Associated With High-dose Diphenhydramine Use Complicating Abdominoplasty and Mastopexy.
Plast Reconstr Surg Glob Open
March 2025
Department of Surgery, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Chappaqua, NY.
Serotonin syndrome is a condition associated with increased serotonergic transmission in the central nervous system. Although shortfalls with diagnostic criteria have led to misleading associations with multiple medications, a possible precipitant is diphenhydramine. Documentation of such an association would prove important for physician practice, as diphenhydramine remains one of the most popular antihistamines available.
View Article and Find Full Text PDFAssociation of Early Blood Pressure Levels and Outcomes in Ischemic Stroke Treated With Intravenous Thrombolysis: A Prospective Cohort Study.
CNS Neurosci Ther
March 2025
Department of Neurology, First Affiliated Hospital of Wenzhou Medical University, Shanghai, China.
Background And Purpose: Current guidelines for acute ischemic stroke (AIS) treatment recommend a lenient upper blood pressure (BP) threshold of 185/110 mmHg. However, stricter BP control has been reported to improve prognosis. This study aims to identify the optimal BP range following thrombolysis.
View Article and Find Full Text PDFSystemic Administration of the Phytochemical, Myricetin, Attenuates the Excitability of Rat Nociceptive Secondary Trigeminal Neurons.
Molecules
February 2025
Laboratory of Food and Physiological Sciences, Department of Life and Food Sciences, School of Life and Environmental Sciences, Azabu University, 1-17-71, Fuchinobe, Chuo-ku, Sagamihara 252-5201, Kanagawa, Japan.
While the modulation of the excitatory and inhibitory neuronal transmission by the phytochemical flavonoid, myricetin (MYR), has been noted in the nervous system, the way in which MYR affects the excitability of nociceptive sensory neurons in vivo remains to be established. This study aimed to explore whether administering MYR intravenously, in acute doses, to rats, diminishes the excitability of SpVc wide-dynamic range (WDR) spinal trigeminal nucleus caudalis (SpVc) neurons in response to nociceptive and non-nociceptive mechanical stimulation in vivo. Recordings of extracellular single units were obtained from SpVc neurons when orofacial mechanical stimulation was applied to anesthetized rats.
View Article and Find Full Text PDFRapid resolution of newly formed carotid free-floating thrombus through anticoagulation therapy.
BMC Neurol
March 2025
Department of Neurology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510655, China.
Background: Carotid free-floating thrombi (CFFT) are uncommon but pose a high risk of embolic stroke. While vascular intervention is often favored, this case study demonstrates the potential of short-term anticoagulation, guided by thorough imaging, as an alternative treatment strategy.
Case Presentation: We present a patient with an acute ischemic stroke (NIHSS 15) due to middle cerebral artery (MCA) occlusion.
Low leucine levels in the blood enhance the pathogenicity of neonatal meningitis-causing Escherichia coli.
Nat Commun
March 2025
National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, TEDA Institute of Biological Sciences and Biotechnology, Nankai University, Tianjin, 300457, China.
Neonatal bacterial meningitis is associated with substantial mortality and morbidity worldwide. Neonatal meningitis-causing Escherichia coli (NMEC) is the most common gram-negative bacteria responsible for this disease. However, the interactions of NMEC with its environment within the host are poorly understood.
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