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[Translated article] Use of Anifrolumab in Systemic Lupus Erythematosus, Cutaneous Lupus Erythematosus, and Other Autoimmune Dermatoses.

Actas Dermosifiliogr

January 2025

Servicio de Dermatología, Hospital de Figueres, Fundació Salut Empordà, Girona, Spain; Servicio de Dermatología, Hospital Clínic de Barcelona, Universitat de Barcelona, Barcelona, Spain. Electronic address:

Article Synopsis
  • Anifrolumab is a drug that blocks a specific receptor (IFNAR1) and is approved for treating moderate-to-severe systemic lupus erythematosus (SLE).
  • * In clinical trials, it has shown effectiveness for skin-related lupus issues, even though it's not specifically approved for cutaneous lupus erythematosus (CLE).
  • * Ongoing studies aim to assess its effectiveness for different types of lupus and related conditions, while its common side effects include respiratory infections and herpes zoster.
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Background: Dermatomyositis (DM) manifests as an autoimmune and inflammatory condition, clinically characterized by subacute progressive proximal muscle weakness, rashes or both along with extramuscular manifestations. Literature indicates that DM shares common risk factors with atherosclerosis (AS), and they often co-occur, yet the etiology and pathogenesis remain to be fully elucidated. This investigation aims to utilize bioinformatics methods to clarify the crucial genes and pathways that influence the pathophysiology of both DM and AS.

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Purpose: To report a rare case of bilateral Purtscher-like retinopathy (PLR) in a young adult diagnosed with dermatomyositis.

Method: A case report with multi-modal imaging.

Result: A 17-year-old male presented with subacute marked diminution of vision along with arthralgia, weakness of all four limbs and development of multiple rashes around body.

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