The effect of 3-, 6- and 12-day courses of anti-lymphocytic IgG treatment (1 ml of 2 g/100 ml) on the primary humoral response of random bred Wistar rats has been investigated. The primary response to alum precipitated bovine serum albumin was suppressed by all these courses. In contrast however the primary response to sheep erythrocytes was suppressed by the 6-day treatment alone or by a 3-day course augmented with azathioprine treatment. Additional experiments performed in hooded rats confirm that prolonged courses of anti-lymphocytic globulin failed to exert an antidotal effect.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1579013 | PMC |
Publication Analysis
Top Keywords
Similar Publications
A therapeutic trial of anti-lymphocytic globulin in acute ulcerative colitis.
Digestion
September 1980
The results of the preliminary part of a controlled therapeutic trial of antilymphocytic globulin (ALG) in severe acute ulcerative colitis are presented. 10 patients have been studied in this part of the trial, 5 receiving standard treatment with corticosteroids, and 5 receiving ALG, in a dose of 1 g daily for 5 days, in addition to the standard treatment. No difference has been observed in the clinical course of the patients in the two groups.
View Article and Find Full Text PDFHeterologous anti-lymphocyte sera were demonstrated to induce a cytotoxic potential in normal non-immunized human lymphocytes against allogeneic fibroblast target cells. The cytotoxicity-inducing capacity was restricted to certain dilutions of anti-lymphocytic serum above and below which no cytotoxic effect was obtained. This optimal concentration shifted towards higher dilutions in sera taken late during the immunization course.
View Article and Find Full Text PDFFurther studies on the effect of anti-lymphocytic antibody on humoral antibody formation.
Clin Exp Immunol
November 1968
The effect of 3-, 6- and 12-day courses of anti-lymphocytic IgG treatment (1 ml of 2 g/100 ml) on the primary humoral response of random bred Wistar rats has been investigated. The primary response to alum precipitated bovine serum albumin was suppressed by all these courses. In contrast however the primary response to sheep erythrocytes was suppressed by the 6-day treatment alone or by a 3-day course augmented with azathioprine treatment.
View Article and Find Full Text PDFEPIDEMIC KERATOCONJUNCTIVITIS : I. ISOLATION AND IDENTIFICATION OF A FILTERABLE VIRUS.
J Exp Med
January 1943
Departments of Ophthalmology and Bacteriology, College of Physicians and Surgeons, Columbia University, and the Institute of Ophthalmology, Presbyterian Hospital, New York.
1. A virus has been isolated from two patients suffering with epidemic keratoconjunctivitis. 2.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!