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Isolation and Functional Characterization of Endophytic Bacteria from Muscadine Grape Berries: A Microbial Treasure Trove.
Cells
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Center for Viticulture & Small Fruit Research, Florida A&M University, Tallahassee, FL 32317, USA.
Muscadine grapes are renowned for their unique traits, natural disease resistance, and rich bioactive compounds. Despite extensive research on their phytochemical properties, microbial communities, particularly endophytic bacteria, remain largely unexplored. These bacteria play crucial roles in plant health, stress tolerance, and ecological interactions.
View Article and Find Full Text PDFACA-24-3995.Highlighted: Determination of lopinavir and ritonavir in hERG solution to support in vitro hERG block potency assessment using LC-MS/MS: The challenge of poor drug solubility.
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April 2025
Division of Applied Regulatory Science, Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD, 20993, USA.
Background: ICH-S7B recommends assessing hERG channel block using patch clamp method to understand the risk of clinical QT prolongation and the associated rare but potentially fatal ventricular tachyarrhythmia, Torsade de Pointes. Drug concentrations exposed to the cells during hERG assays may differ from the intended concentrations due to either human errors or drug properties leading to drug loss. Concentration verification is challenging for drugs with limited solubility, samples may contain solutes and insoluble particles that may solubilize during sample analysis and resulting in inaccurate measurements of cell exposure.
View Article and Find Full Text PDFCharacterization of Streptomyces species with poly(3-hydroxybutyrate) degradation capabilities isolated from rice field soil.
Int J Biol Macromol
March 2025
Green & Sustainable Materials R&D Department, Korea Institute of Industrial Technology (KITECH), Cheonan 31056, Republic of Korea. Electronic address:
The shift towards sustainable alternatives to petroleum-based polymers has become essential for addressing environmental challenges. Among these alternatives, bio-plastics such as poly(3-hydroxybutyrate) (PHB) have gained considerable attention due to their biodegradability into water and carbon dioxide through microbial activity. PHB is one of the most widely commercialized bio-plastics.
View Article and Find Full Text PDFEzetimibe Alters Micelle Structure and Reduces Niemann-Pick C1-like 1-Mediated Absorption of Vitamins E and K in CaCo-2 Cells.
J Pharm Sci
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Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata, Osaka, Japan. Electronic address:
Ezetimibe (EZE) is known to inhibit cholesterol absorption by targeting Niemann-Pick C1-like 1 (NPC1L1). However, its effects on the absorption of fat-soluble vitamins, such as Vitamin E and Vitamin K, remain unclear. This study investigates how EZE impacts micellar properties and vitamin absorption.
View Article and Find Full Text PDFBiotic and abiotic drivers of soil carbon, nitrogen and phosphorus and metal dynamic changes during spontaneous restoration of Pb-Zn mining wastelands.
J Hazard Mater
March 2025
Yunnan Key Laboratory for Plateau Mountain Ecology and Restoration of Degraded Environments, School of Ecology and Environmental Sciences, Yunnan University, Kunming 650091, China; Yunnan International Joint Research Center of Plateau Lake Ecological Restoration and Watershed Management, Yunnan University, Kunming 650091, China. Electronic address:
The biotic and abiotic mechanisms that drive important biogeochemical processes (carbon, nitrogen, phosphorus and metals dynamics) in metal mine revegetation remains elusive. Metagenomic sequencing was used to explored vegetation, soil properties, microbial communities, functional genes and their impacts on soil processes during vegetation restoration in a typical Pb-Zn mine. The results showed a clear niche differentiation between bacteria, fungi and archaea.
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