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The problem of searching different immunologic, clinical and laboratory signs and parameters characterizing evaluation of the rheumatoid arthritis (RA) and the early prognosis of its outcome cause interest to studying peculiarities of immunologic status and changes of some serologic markers in different RA forms. The comparison of clinico-immunologic data in seropositive and seronegative patients revealed the most pronounced changes in patients with extraarticular manifestations (EAM), positive to IgM-RF. In this case the direct correlation with RA severity was seen in the both RA forms.

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Asymmetric affection of the major lower limb joints is a characteristic feature of the joint syndrome in yersiniosis-associated arthritis. The sacroiliac articulations are frequently (47% cases) involved. In addition, yersiniosis-associated arthritis concurs with the signs and symptoms of systemic disease--gastroenterocolitis, myocardiopathy and myocarditis, erythema nodosum, hepatitis, urethritis, conjunctivitis, myositis and myalgia, enteropathy; changes in the CNS typical for the astheno-neurotic syndrome are frequently present.

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