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Clinical relevance of macromolecular complexes involving integrins, potassium and sodium ion channels and the sodium/proton antiporter in human breast cancer.
Cancer Cell Int
January 2025
Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Background: Mounting evidence underline the relevance of macromolecular complexes in cancer. Integrins frequently recruit ion channels and transporters within complexes which behave as signaling hubs. A complex composed by β1 integrin, hERG1 K channel, the neonatal form of the Na channel Na 1.
View Article and Find Full Text PDFGlobal, regional, and national burden of esophageal cancer using the 2019 global burden of disease study.
Sci Rep
January 2025
Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, China.
Esophageal cancer, with its aggressive nature and high mortality, poses diverse epidemiological challenges worldwide. Over the past three decades, esophageal cancer has exhibited a substantial global burden, marked by a significant increase in absolute numbers, contrasting with a decline in age-standardized metrics. Prevalence nearly doubled, reaching 0.
View Article and Find Full Text PDFAnthocyanin can improve the survival of rice seeds from solar light outside the international space station.
Life Sci Space Res (Amst)
February 2025
School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
A purple-pigmented (purple) rice seeds containing an anthocyanin, a major class of flavonoids, and their isogenic non-pigmented (white) seeds were exposed outside of the international space station (ISS) to evaluate the impact of anthocyanin on seed viability in space. The rice seeds were placed in sample plates at the exposed facility of ISS for 440 days, with the bottom layer seeds exposed to space radiation and the top layer seeds exposed to both solar light and space radiation. Though the seed weight of both purple and white seeds decreased after exposure to outer space, growth percentages after germination of purple and white seeds in the top layer were 55 and 15 %, respectively, compared to those in the bottom layer 100 and 70 %, respectively.
View Article and Find Full Text PDFThe International Association for the Study of Lung Cancer Staging Project: The Database and Proposal for the Revision of the Staging of Pulmonary Neuroendocrine Carcinoma in the Forthcoming Ninth Edition of the TNM Classification for Lung Cancer.
J Thorac Oncol
January 2025
Division of Thoracic Surgery, Keio University School of Medicine, Tokyo, Japan.
Introduction: Pulmonary high-grade neuroendocrine carcinoma (NEC) includes small cell lung carcinoma (SCLC) and large cell neuroendocrine carcinoma (LCNEC). The seventh and eighth editions of the TNM classification for lung cancer confirmed the applicability of this staging system for SCLC. With the proposal of N2 and M1c subcategories for the ninth edition classification, we assessed the applicability to NECs.
View Article and Find Full Text PDFIntegrating Nutritional Status and Hematological Biomarkers for Enhanced Prognosis Prediction in Glioma Patients: A Systematic Review.
Clin Nutr ESPEN
January 2025
Department of Experimental and Clinical Biomedical sciences "Mario Serio", University of Florence, Florence, Italy; Azienda Ospedaliero-Universitaria Careggi, Radiation Oncology Unit, Florence, Italy.
Purpose: Multiple inflammatory and nutritional biomarkers have been established as independent prognostic factors across various solid tumors, but their role in outcomes prediction for glioma is still under investigation. Aim of the present systematic review is to report the available evidence regarding the impact of nutritional assessment and intervention for glioma prognosis and patients' quality of life (QoL).
Materials And Methods: Our systematic review conformed to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines.
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