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Hemotrophic mycoplasmas induce programmed cell death in red blood cells.
Cell Physiol Biochem
October 2011
Institute of Veterinary Bacteriology, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.
Hemotrophic mycoplasmas (HM) are uncultivable bacteria found on and in the red blood cells (RBCs). The main clinical sign of HM infections is the hemolytic anemia. However, anemia-inducing pathogenesis has not been totally clarified.
View Article and Find Full Text PDFRole of the transmembrane sequence of spleen focus-forming virus gp55 in erythroleukemogenesis.
Virology
December 1998
Department of Microbiology, New York University Medical Center, New York, USA.
The membrane glycoprotein encoded by the env gene of either the polycythemia- or anemia-inducing spleen focus-forming virus (SFFVp or SFFVa, respectively) is responsible for the induction of erythroleukemia in mice. It has been shown that the SFFVp glycoprotein, gp55, interacts with the erythropoietin receptor (EPO-R) and promotes EPO-independent proliferation of an EPO-R-expressing hematopoietic cell line, Ba/F3 (Li et al., Nature 343:762, 1990).
View Article and Find Full Text PDFRapid induction of mouse virus-like (VL30) element transcripts by erythropoietin in murine erythroid progenitor cells.
Blood
July 1993
Department of Pharmacology, University of Missouri-Columbia, School of Medicine, Columbia 65212.
We examined the activation of genes induced by erythropoietin (Epo) in erythroid progenitor cells that were isolated from the spleens of mice infected with anemia-inducing strain of the Friend virus. These erythroid progenitor cells, termed FVA cells, undergo in vitro differentiation to erythrocytes under the influence of Epo within 2 to 3 days. We used a differential hybridization procedure to screen a cDNA library constructed from FVA cells that were treated with Epo 2U/mL in the absence of serum for 2 hours.
View Article and Find Full Text PDFMorphological changes in erythroblasts during erythropoietin-induced terminal differentiation in vitro.
Exp Hematol
October 1988
Division of Hematology, Vanderbilt University, Nashville, Tennessee.
Immature murine erythroblasts infected with the anemia-inducing strain of Friend virus (FVA cells) differentiate in vitro under the influence of erythropoietin (EP). These cells were used as a model for the examination of morphological changes occurring during terminal erythroid differentiation. FVA cells differentiate more completely in vitro in response to EP than continuous erythroleukemia cell lines do in response to chemical induction.
View Article and Find Full Text PDFPremature translation termination mediates triosephosphate isomerase mRNA degradation.
Mol Cell Biol
February 1988
Department of Human Genetics, Roswell Park Memorial Institute, Buffalo, New York 14263.
We characterized an anemia-inducing mutation in the human gene for triosephosphate isomerase (TPI) that resulted in the production of prematurely terminated protein and mRNA with a reduced cytoplasmic half-life. The mutation converted a CGA arginine codon to a TGA nonsense codon and generated a protein of 188 amino acids, instead of the usual 248 amino acids. To determine how mRNA primary structure and translation influence mRNA stability, in vitro-mutagenized TPI alleles were introduced into cultured L cells and analyzed for their effect on TPI RNA metabolism.
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