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Berberine alleviates chronic pain-induced anxiety-like behaviors by inhibiting the activation of VLT-projecting cACC (Cg2) neurons.
Commun Biol
December 2024
Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Department of Neurobilolgy and Acupuncture Reseach, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
Chronic pain is often accompanied by anxiety, and gradually increasing anxiety makes the pain itself more protracted. Berberine has been found to be able to cross the blood-brain barrier to treat psychiatric disorders, but its neurocirculatory mechanisms remain unclear. Here, we found that neurons in cingulate area 2 (Cg2) of the caudal anterior cingulate cortex (cACC), but not in Cg1 of the cACC, projected to the ventral lateral thalamus (VLT).
View Article and Find Full Text PDFImpaired Neurocirculatory Control in Chronic Kidney Disease: New Evidence for Blunted Sympathetic Baroreflex and Reduced Sympathetic Transduction.
Function (Oxf)
November 2024
Division of Renal Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA, 30322, USA.
Chronic kidney disease (CKD) is characterized by over-activation of the sympathetic nervous system (SNS) that increases cardiovascular risk. Whether sympathetic baroreflex sensitivity (sBRS) is impaired or intact in CKD remains under-studied and controversial. Furthermore, the downstream effect of SNS activation on blood pressure transduction has not been previously examined in CKD.
View Article and Find Full Text PDFCentral α-adrenergic mechanisms regulate human sympathetic neuronal discharge strategies.
J Physiol
August 2024
Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA.
The present study investigated the impact of central α-adrenergic mechanisms on sympathetic action potential (AP) discharge, recruitment and latency strategies. We used the microneurographic technique to record muscle sympathetic nerve activity and a continuous wavelet transform to investigate postganglionic sympathetic AP firing during a baseline condition and an infusion of a α-adrenergic receptor agonist, dexmedetomidine (10 min loading infusion of 0.225 µg kg; maintenance infusion of 0.
View Article and Find Full Text PDFAdvancements in the neurocirculatory reflex response to hypoxia.
Am J Physiol Regul Integr Comp Physiol
July 2024
Centre for Heart, Lung, and Vascular Health, School of Health and Exercise Sciences, University of British Columbia, Kelowna, British Columbia, Canada.
Hypoxia is a pivotal factor in the pathophysiology of various clinical conditions, including obstructive sleep apnea, which has a strong association with cardiovascular diseases like hypertension, posing significant health risks. Although the precise mechanisms linking hypoxemia-associated clinical conditions with hypertension remains incompletely understood, compelling evidence suggests that hypoxia induces plasticity of the neurocirculatory control system. Despite variations in experimental designs and the severity, frequency, and duration of hypoxia exposure, evidence from animal and human models consistently demonstrates the robust effects of hypoxemia in triggering reflex-mediated sympathetic activation.
View Article and Find Full Text PDFThe exercise pressor reflex - a pressure-raising mechanism with a limited role in regulating leg perfusion during locomotion in young healthy men.
J Physiol
October 2023
Geriatric Research, Education, and Clinical Center, Salt Lake City VAMC, UT, USA.
We investigated the role of the exercise pressor reflex (EPR) in regulating the haemodynamic response to locomotor exercise. Eight healthy participants (23 ± 3 years, : 49 ± 6 ml/kg/min) performed constant-load cycling exercise (∼36/43/52/98% ; 4 min each) without (CTRL) and with (FENT) lumbar intrathecal fentanyl attenuating group III/IV locomotor muscle afferent feedback and, thus, the EPR. To avoid different respiratory muscle metaboreflex and arterial chemoreflex activation during FENT, subjects mimicked the ventilatory response recorded during CTRL.
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