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Circadian pattern in restless legs syndrome.
Handb Clin Neurol
January 2025
Department of Neurology, Medical University Innsbruck, Innsbruck, Austria.
This chapter provides an overview of circadian pattern in restless legs syndrome (RLS). Circadian variation of symptoms is a known feature of RLS. According to one of the five essential criteria for RLS diagnosis, symptoms "only occur or are worse in the evening or at night than during the day.
View Article and Find Full Text PDFBoNT/Action beyond neurons.
Toxicon
January 2025
National Research Council of Italy, Institute of Biochemistry and Cell Biology, 00015, Monterotondo, RM, Italy. Electronic address:
Botulinum neurotoxin type A (BoNT/A) has expanded its therapeutic uses beyond neuromuscular disorders to include treatments for various pain syndromes and neurological conditions. Originally recognized for blocking acetylcholine release at neuromuscular junctions, BoNT/A's effects extend to both peripheral and central nervous systems. Its ability to undergo retrograde transport allows BoNT/A to modulate synaptic transmission and reduce pain centrally, influencing neurotransmitter systems beyond muscle control.
View Article and Find Full Text PDFMyiasis in a spinal cord injury patient with indwelling catheter: A case report from Gondar, Ethiopia.
Int J Surg Case Rep
January 2025
Department of Surgery, College of Medicine and Health Sciences, Comprehensive Specialized Hospital, University of Gondar, Gondar, Ethiopia.
Introduction And Importance: Myiasis is an overlooked public health issue, with urogenital myiasis (UGM) being particularly rare, as evidenced by only 59 reported cases worldwide from 1975 to 2017. There is a notable scarcity of cases involving patients with prolonged catheter use related to SCI. The interaction of SCI with the complications associated with indwelling urinary devices is less frequently discussed in prior literature.
View Article and Find Full Text PDFSingle-cell chromatin accessibility landscape profiling reveals the diversity of epigenetic regulation in the rat nervous system.
Sci Data
January 2025
BGI Research, Shenzhen, 518083, China.
The mammalian nervous system controls complex functions through highly specialized and interacting structures. Single-cell sequencing can provide information on cell-type-specific chromatin structure and regulatory elements, revealing differences in chromatin organization between different cell types and their potential roles of these differences in brain function. Here, we generated a chromatin accessibility dataset through single-cell ATAC-seq of 174,593 high-quality nuclei from 16 adult rat brain regions.
View Article and Find Full Text PDFImpact of Spinal Instrumentation on Early Postoperative Inflammatory Markers: A Comparative Analysis in the Same Patient Cohort with or without Instrumentation.
World Neurosurg
January 2025
Department of Orthopedic Surgery, Osaka Rosai Hospital, 1179-3 Nagasonecho, Kita-ku, Sakai city, Osaka 5918025, Japan.
Backgrounds: Postoperative inflammatory parameters are important markers of surgical site infection. Some authors have reported that spine surgery with instrumentation elevates CRP levels more than that without instrumentation does. However, those studies compared early postoperative inflammatory markers with or without instrumentation in different patients, although CRP levels vary widely among patients.
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