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Cerebral collateral flow state in acute ischemic stroke correlates with clinical functional outcomes in non-thrombectomy patients.
J Stroke Cerebrovasc Dis
December 2024
University of South Carolina School of Medicine and Prisma Health Midlands, Department of Neurology, Columbia, SC. Electronic address:
Introduction: Hypoperfusion index ratio (HIR) measured by computerized tomography perfusion (CTP) has been shown to predict collateral flow state in acute ischemic stroke (AIS). Low HIR (<0.4) is indicative of good collateral flow state.
View Article and Find Full Text PDFEvaluating Sperm Recovery Time and Efficacy of Monotherapy Combination Therapies in Men with Congenital Hypogonadotropic Hypogonadism: A Systematic Review and Meta-Analysis.
World J Mens Health
October 2024
Desai Sethi Urology Institute, Miller School of Medicine, University of Miami, Miami, FL, USA.
Purpose: There is a lack of pooled data exploring the time and rates for human chorionic gonadotropin (hCG) monotherapy combination therapies (hCG+human menopausal gonadotropin or recombinant human follicle-stimulating hormone) to restore spermatogenesis in azoospermic men with congenital hypogonadotropic hypogonadism (CHH). We aimed to investigate the time and rates to recover spermatogenesis among azoospermic CHH men receiving monotherapy combination therapy.
Materials And Methods: We conducted a systematic review and meta-analysis following the PRISMA guidelines.
Effect of spirulina on risk of hospitalization among patients with COVID-19: the TOGETHER randomized trial.
Am J Clin Nutr
September 2024
Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada; Purpose Life Sciences, Vancouver, British Columbia, Canada. Electronic address:
Background: Algae-derived nutraceuticals, such as spirulina, have been reported to have biological activities that may minimize clinical consequences to COVID-19 infections.
Objectives: This study aimed to determine whether spirulina is an effective treatment for high-risk patients with early COVID-19 in an outpatient setting.
Methods: The TOGETHER trial is a placebo-controlled, randomized, platform trial conducted in Brazil.
Protocol for Improving Care by FAster risk-STratification through use of high sensitivity point-of-care troponin in patients presenting with possible acute coronary syndrome in the EmeRgency department (ICare-FASTER): a stepped-wedge cluster randomised quality improvement initiative.
BMJ Open
June 2024
Medicine, University of Otago Christchurch, Christchurch, New Zealand
Introduction: Clinical assessment in emergency departments (EDs) for possible acute myocardial infarction (AMI) requires at least one cardiac troponin (cTn) blood test. The turn-around time from blood draw to posting results in the clinical portal for central laboratory analysers is ~1-2 hours. New generation, high-sensitivity, point-of-care cardiac troponin I (POC-cTnI) assays use whole blood on a bedside (or near bedside) analyser that provides a rapid (8 min) result.
View Article and Find Full Text PDFImplementing enhanced extracorporeal membrane oxygenation for CPR (ECPR) in the emergency department.
Int J Emerg Med
June 2024
University of Sydney Medical School, Sydney, Australia.
Refractory out-of-hospital cardiac arrest (OHCA) has a very poor prognosis, with survival rates at around 10%. Extracorporeal membrane oxygenation (ECMO) for patients in refractory arrest, known as ECPR, aims to provide perfusion to the patient whilst the underlying cause of arrest can be addressed. ECPR use has increased substantially, with varying survival rates to hospital discharge.
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