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A blood-free modeling approach for the quantification of the blood-to-brain tracer exchange in TSPO PET imaging.
Front Neurosci
July 2024
Department of Information Engineering, University of Padova, Padova, Italy.
Introduction: Recent evidence suggests the blood-to-brain influx rate ( ) in imaging as a promising biomarker of blood-brain barrier () permeability alterations commonly associated with peripheral inflammation and heightened immune activity in the brain. However, standard compartmental modeling quantification is limited by the requirement of invasive and laborious procedures for extracting an arterial blood input function. In this study, we validate a simplified blood-free methodologic framework for estimation by fitting the early phase tracer dynamics using a single irreversible compartment model and an image-derived input function ().
View Article and Find Full Text PDFDefining reference values of arterioles in healthy individuals for studies with adaptive optics imaging.
Front Ophthalmol (Lausanne)
March 2024
University Eye Hospital, Center for Ophthalmology, University of Tübingen, Tübingen, Germany.
Purpose: To investigate age-dependent wall to lumen ratio (WLR) reference values for healthy individuals in adaptive optics imaging (AO). WLR serves as an objective, dimensionless parameter for the evaluation of structural changes in vessels caused by conditions like arterial hypertension, diabetes or vascular stenosis.
Methods: 50 right eyes of healthy individuals were examined by adaptive optics imaging.
Migraines constitute a neurological disorder characterized by severe and recurrent headaches, significantly impacting the quality of life especially when unresponsive to treatment. This is particularly pronounced in individuals with difficult-to-treat migraines, leading to heightened physical and psychosocial disability. The study aims to design and implement a psychological intervention protocol (MIDITRA) focused on improving the physical and psychological well-being of those suffering from difficult-to-treat migraines.
View Article and Find Full Text PDFA novel simulated media system for in vitro evaluation of bioequivalent intestinal drug solubility.
Eur J Pharm Biopharm
June 2024
Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, United Kingdom. Electronic address:
Article Synopsis
- Orally administered solid drugs need to dissolve in the gastrointestinal tract for absorption, but measuring solubility in human intestinal fluid (HIF) is complicated due to variability in fasting and fed states.
- This study compares solubility measurements from literature with a new in vitro simulated intestinal fluid system that accurately reflects fasted (Fa9SIF) and fed (Fe9SIF) conditions.
- The findings suggest that this new methodology for determining intestinal solubility can enhance drug formulation development and potentially apply to other complex fluid systems.
Minimally invasive micro sclerostomy (MIMS) procedure in the treatment of open-angle glaucoma.
BMC Ophthalmol
March 2024
Department of Ophthalmology, Rabin Medical Center- Beilinson Hospital, 39 Jabotinski St, Petach Tikva, Israel.
Background: To evaluate the safety and efficacy of the Minimally Invasive Micro Sclerotomy (MIMS) procedure in the management of uncontrolled open-angle glaucoma.
Methods: A prospective, open-label, single-arm clinical evaluation with intra-subject comparisons performed at the Ophthalmologic Center after S.V.
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