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A new Leydig cell-exclusive Cre line allows lineage tracing of both fetal and adult Leydig cell populations in the mouse.
Endocrinology
January 2025
Reproduction, Mother and Child Health, Centre de recherche du centre hospitalier universitaire de Québec - Université Laval, Québec City, Québec, Canada, G1V 4G2.
Leydig cells produce hormones that are required for male development, fertility, and health. Two Leydig cell populations produce these hormones but at different times during development: fetal Leydig cells which are active during fetal life and adult Leydig cells that are functional postnatally. Historically, our ability to understand the origin and function of Leydig cells has been made difficult by the lack of genetic models to exclusively target these cells.
View Article and Find Full Text PDFCountry of origin and prices of systemic antibiotics in Vietnam: a multicentre retrospective study.
JAC Antimicrob Resist
February 2025
Department of Infectious Diseases, Hanoi Medical University, No 1 Ton That Tung Street, Dong Da District, Hanoi, Vietnam.
Background: Local production of antibiotics is essential for improving access to treatment of clinical infection and avoiding vulnerability to expensive drug imports.
Objectives: To describe the country of origin and cost of antibiotics in Vietnam.
Methods: This was an observational study.
Novel Missense DNA Variants in the IL2RG Gene Identified in Slovak X-linked Severe Combined Immunodeficiency Disease Patients: A Case Report.
Cureus
December 2024
Laboratory of Genomic Medicine, GHC GENETICS SK, Comenius University Science Park, Bratislava, SVK.
X-linked severe combined immunodeficiency disease (X-SCID) is a form of inborn errors of immunity (IEI) associated with causal DNA variants of the gene. Patients with X-SCID are characterized by a combination of cellular and humoral immunodeficiencies associated with increased susceptibility to infections. The presented cases constituted two unrelated male patients from the Slovak population.
View Article and Find Full Text PDFA Rare Case of Lemierre's Syndrome Caused by Streptococcus pyogenes.
Cureus
December 2024
Internal Medicine Department, Unidade Local de Saúde Entre Douro e Vouga, Santa Maria da Feira, PRT.
Lemierre's syndrome (LS) is a rare condition characterized by septic thrombophlebitis of the internal jugular vein (IJV). Typically, the primary infection originates in the oropharynx, progressing to the lateral pharyngeal space, IJV, and potentially leading to bacteremia. Through septic embolization, these patients can develop severe complications, underscoring the importance of early diagnosis.
View Article and Find Full Text PDFIdiopathic Transient Osteoporosis of the Hip: A Frequently Overlooked and Misdiagnosed Cause of Hip Pain.
Cureus
December 2024
Orthopedics and Traumatology, Unidade Local de Saúde de Viseu Dão-Lafões, Viseu, PRT.
Idiopathic transient osteoporosis of the hip (ITOH) is a rare and self-limiting condition of unknown origin, typically responding well to conservative treatment. It is characterized by progressive pain, claudication, and osteoporosis of the femoral head, while the joint line remains preserved. Early clinical and radiological findings can be misinterpreted as aseptic necrosis, infection, or neoplastic processes, making careful exclusion of these conditions essential.
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