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Topical losartan ophthalmic drops - a review of corneal wound healing and topical losartan for managing corneal haze and potential future indications.
Graefes Arch Clin Exp Ophthalmol
December 2024
Instituto de Microcirugía Ocular (IMO) Barcelona Grupo Miranza, Barcelona, Spain.
Article Synopsis
- - Corneal haze results from abnormal healing processes following injuries or surgeries, causing vision impairment due to eye opacity and irregularities, often linked to myofibroblast formation triggered by inflammation.
- - Major causes of corneal haze include surgical procedures like PRK and LASIK, as well as non-surgical factors such as trauma and infections, with research focusing on the TGFβ pathway and inflammation management methods.
- - Losartan, usually used for treating high blood pressure, shows promise in ophthalmology for reducing corneal fibrosis after various injuries and surgeries, leading to this review of its effectiveness and potential future applications in treating corneal haze.
Microbial communities in slow sand filters for drinking water treatment adapt to organic matter altered by ozonation.
Water Res
February 2025
Division of Applied Microbiology, Department of Chemistry, Lund University, P.O. Box 124, SE-221 00 Lund, Sweden; Water Resources Engineering, Department of Building and Environmental Technology, Lund University, SE-221 00 Lund, Sweden.
Changing natural organic matter quality from anthropogenic activity and stricter requirements for micropollutant removal challenges existing systems for drinking water production. Ozonation of water followed by biofiltration, such as passage through a slow sand filter (SSF), is a partial solution. Biofiltration relies on biofilms (microbial communities within extracellular matrices).
View Article and Find Full Text PDFContent-Related Quality Control of Water- and Fat-Soluble Vitamins in Fortified Non-Alcoholic Beverages.
Nutrients
November 2024
Faculty of Pharmacy, University of Ljubljana, Aškerčeva cesta 7, 1000 Ljubljana, Slovenia.
Background/objectives: Vitamin-fortified non-alcoholic beverages (VFNABs) are rising in popularity and availability. However, owing to their regulation as foods, there are also growing quality and safety concerns. Therefore, we aimed to provide an overview of the content-related quality of VFNABs on the Slovenian market.
View Article and Find Full Text PDFWaterless structures in the Protein Data Bank.
IUCrJ
November 2024
Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznań, Poland.
The absence of solvent molecules in high-resolution protein crystal structure models deposited in the Protein Data Bank (PDB) contradicts the fact that, for proteins crystallized from aqueous media, water molecules are always expected to bind to the protein surface, as well as to some sites in the protein interior. An analysis of the contents of the PDB indicated that the expected ratio of the number of water molecules to the number of amino-acid residues exceeds 1.5 in atomic resolution structures, decreasing to 0.
View Article and Find Full Text PDFTuning the Properties of Polyvinylidene Fluoride/Alkali Lignin Membranes to Develop a Biocatalytic Membrane Reactor for an Organophosphorus Pesticide Degradation.
Membranes (Basel)
August 2024
National Research Council of Italy, Institute on Membrane Technology, CNR-ITM, 87036 Rende, Italy.
It has been observed that the immobilization of a phosphotriesterase enzyme (PTE) onto polyvinylidene fluoride (PVDF) membranes significantly decreased the enzyme activity, and this negative effect was attributed to the hydrophobic character of the membrane. The indirect indication of this reason was that the same enzyme immobilized on other membrane materials bearing hydrophilic character showed better performance. In this work, we provide direct evidence of the mechanism by immobilizing a PTE on a PVDF membrane hydrophilized by blending it with alkali lignin (AL).
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