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Neuroprotective effects of chitinase-1 and calcitonin gene-related peptide on Alzheimer's disease by promoting lysosomal function.
J Alzheimers Dis
January 2025
Department of Geriatrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Background: The amyloid cascade hypothesis still dominates in Alzheimer's disease (AD), and the acceleration of the clearance efficiency of amyloid-β (Aβ) has been always considered as an effective treatment option to slow the occurrence and progression of AD.
Objective: This study aims to explore the role of zkscan3 and its related pathways in AD of the microglia-mediated pathogenesis, and whether the combined effect of drugs can exert neuroprotective function.
Methods: N9 mouse microglia and HT-22 mouse hippocampal neurons were randomly divided into 6 groups, qRT-PCR technique was used to detect the gene expression level of zkscan3 and the genes related to lysosome generation and function.
IgE-based analysis of sensitization and cross-reactivity to yellow mealworm and edible insect allergens before their widespread dietary introduction.
Sci Rep
January 2025
Department of Experimental Allergology and Immunology, Medical University of Bialystok, Bialystok, Poland.
The European Commission authorized the use of dried yellow mealworm (Tenebrio molitor - TM) as a food ingredient under Regulation EU 2021/882. As TM emerges as an important allergen source, sensitization and allergy to TM in various populations need investigation. The aim of this study was to assess the incidence of sensitization to TM before its introduction as a food ingredient in Poland, as well as checking the occurrence of co-sensitivity to TM and other invertebrate allergenic extracts and molecules.
View Article and Find Full Text PDFYKL-40, cardiovascular events, and mortality in individuals recently diagnosed with type 2 diabetes: A Danish cohort study.
Diabetes Res Clin Pract
January 2025
Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark.
Aims: We investigated the association of the inflammatory biomarker YKL-40 with cardiovascular events (CVEs) and mortality in individuals with type 2 diabetes.
Methods: We followed 11,346 individuals recently diagnosed with type 2 diabetes for up to 14 years. Baseline YKL-40 levels (measured in 9,010 individuals) were grouped into percentiles (0-33 %, 34-66 %, 67-90 %, and 91-100 %) and analyzed continuously (per 1 SD log increment), with comparisons to CRP (measured in 9,644 individuals).
Plasma Biomarkers of Kidney Health and Mortality in Diabetes and Chronic Kidney Disease in the REGARDS Study.
Clin J Am Soc Nephrol
December 2024
Kidney Health Research Collaborative and Department of Medicine, University of.
Key Points: In diabetes and CKD, creatinine- and cystatin C–based eGFR has a strong inverse correlation with plasma TNF receptor 1, TNF receptor 2, and soluble urokinase-type plasminogen activator receptor. Higher plasma soluble TNF receptors 1 and 2 and soluble urokinase-type plasminogen activator receptor were each individually associated with mortality, independent of baseline kidney measures.
Background: Several plasma biomarkers of kidney health have been associated with CKD progression in persons with diabetes, but their associations with mortality risk have been largely unexplored.
Gene Expression by a Model Fungus in the Ascomycota Provides Insight Into the Decay of Fungal Necromass.
Environ Microbiol
December 2024
Department of Plant and Microbial Biology, College of Biological Sciences, University of Minnesota, Twin Cities, Minnesota, USA.
Article Synopsis
- Dead fungal cells, referred to as necromass, contribute significantly to long-term soil carbon pools, but the genes responsible for their decomposition are not well understood.
- * The study focused on the fungus Trichoderma reesei and its response to low and high melanin levels in the necromass of another fungus, Hyaloscypha bicolor, revealing over 100 up-regulated genes for carbohydrate-active enzymes (CAZymes) in the presence of necromass compared to glucose.
- * Differential expression of specific genes related to proteases and laccases was noted, particularly linked to the breakdown of melanin, offering insights into the factors affecting carbon turnover rates in this underexplored area of soil biology.
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