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Biophysical and biochemical evidence for the role of acetate kinases (AckAs) in an acetogenic pathway in pathogenic spirochetes.
PLoS One
January 2025
Department of Microbiology, UT Southwestern Medical Center, Dallas, TX, United States of America.
Unraveling the metabolism of Treponema pallidum is a key component to understanding the pathogenesis of the human disease that it causes, syphilis. For decades, it was assumed that glucose was the sole carbon/energy source for this parasitic spirochete. But the lack of citric-acid-cycle enzymes suggested that alternative sources could be utilized, especially in microaerophilic host environments where glycolysis should not be robust.
View Article and Find Full Text PDFImpacts of Pta-AckA pathway on CPS biosynthesis and type 3 fimbriae expression in Klebsiella pneumoniae.
J Microbiol Immunol Infect
October 2024
Graduate Institute of Chinese Medicine, School of Chinese Medicine, China Medical University, Taichung, Taiwan; School of Chinese Medicine, China Medical University, Taichung, Taiwan. Electronic address:
Background: Klebsiella pneumoniae is a Gram-negative bacterium that can cause infections, especially in individuals with diabetes. Recently, more hypervirulent strains have emerged, posing a threat even to healthy individuals. Understanding how K.
View Article and Find Full Text PDFAcetyl-CoA synthetase activity is enzymatically regulated by lysine acetylation using acetyl-CoA or acetyl-phosphate as donor molecule.
Nat Commun
July 2024
Department of Synthetic and Structural Biochemistry, Institute of Biochemistry, University of Greifswald, 17489, Greifswald, Germany.
The AMP-forming acetyl-CoA synthetase is regulated by lysine acetylation both in bacteria and eukaryotes. However, the underlying mechanism is poorly understood. The Bacillus subtilis acetyltransferase AcuA and the AMP-forming acetyl-CoA synthetase AcsA form an AcuA•AcsA complex, dissociating upon lysine acetylation of AcsA by AcuA.
View Article and Find Full Text PDFMultiomics analysis revealed that the metabolite profile of raw milk is associated with the lactation stage of dairy cows and could be affected by variations in the ruminal microbiota.
J Dairy Sci
October 2024
College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, China; Key Laboratory of Livestock Biology, Northwest A&F University, Yangling 712100, Shaanxi, China. Electronic address:
Article Synopsis
- - The study investigates how the rumen microbiota and its metabolites affect the nutritional quality of milk at different stages of lactation in dairy cows, using metabolomics and genetic sequencing techniques.
- - Key findings show that certain metabolites in milk, such as l-glutamate and various lipids, vary in concentration depending on the lactation stage, with notable increases in flavor-related compounds during early to mid-lactation.
- - Rumen microbial diversity changes throughout lactation, with specific genera being enriched at different stages; for instance, certain bacteria dominate during peak lactation, while others are more prevalent in early mid-lactation.
Bacteria employ lysine acetylation of transcriptional regulators to adapt gene expression to cellular metabolism.
Nat Commun
February 2024
Institute of Biochemistry, Department of Synthetic and Structural Biochemistry, University of Greifswald, Felix-Hausdorff-Str. 4, 17489, Greifswald, Germany.
The Escherichia coli TetR-related transcriptional regulator RutR is involved in the coordination of pyrimidine and purine metabolism. Here we report that lysine acetylation modulates RutR function. Applying the genetic code expansion concept, we produced site-specifically lysine-acetylated RutR proteins.
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