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Telomeric RNA quadruplexes as targets for cancer prevention: The therapeutic potential of agonodepsides.
J Genet Eng Biotechnol
March 2025
Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India. Electronic address:
Background: Cancer remains an awful challenge, despite years of targeting proteins to control its relentless growth and spread. Fungal metabolites, a treasure of natural chemicals, offer a glimmer of hope. Telomeres, the cellular "caps," are a focal point in cancer research.
View Article and Find Full Text PDFFat absorption and metabolism after Roux-en-Y gastric bypass surgery.
Metabolism
March 2025
Department of Endocrinology, Copenhagen University Hospital Hvidovre, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark. Electronic address:
Background: Triacylglycerol (TAG) plasma excursions after a high-fat meal are blunted after Roux-en-Y gastric bypass (RYGB), but underlying mechanisms are poorly understood. We studied TAG absorption and metabolism in 12 RYGB-operated individuals and 12 unoperated controls (CON) matched on sex, age, and BMI.
Methods: Participants followed a 7-day controlled diet and on day 4 underwent H-MR Spectroscopy of liver TAG and a high-fat liquid meal with oral and intravenous labeled stable isotope metabolites, subcutaneous abdominal fat biopsies, and indirect calorimetry.
Study on yolk iron transportation in chick embryo eggs based on transcriptomics.
Poult Sci
February 2025
Engineering Research Center of Bio-process, Ministry of Education/ School of Food and Biological Engineering, Hefei University of Technology, Hefei 230601, China; Key Laboratory for Agricultural Products Processing of Anhui Province/Key Laboratory for Animal Food Green Manufacturing and Resource Mining of Anhui Province, Hefei 230601, China. Electronic address:
Chick embryo eggs have a complete system of iron release, delivery, and uptake and thus provide a useful tool to study the fast transportation and absorption of iron. Based on this, the regulatory genes and pathways of iron transportation and uptake at the four key stages of chick embryo incubation, days 6, 9, 12, and 15 (E6, E9, E12, and E15), were investigated. Throughout these four key stages, the iron content decreased in egg yolk, increased in chick embryos, and first increased and then decreased in the yolk sac membrane (YSM) with the highest value of 110.
View Article and Find Full Text PDFGrowth patterns and heat tolerance analysis of dwarf chicken with frizzled feather.
Poult Sci
March 2025
College of Coastal Agricultural Sciences, Guangdong Ocean University, Zhanjiang, 524088, Guangdong, China. Electronic address:
Chickens are covered with feathers, lack sweat glands, and are sensitive to the thermal environment. Previously, our group bred a novel dwarf chicken strain with frizzled feather, named as dwarf chicken with frizzled feather (DFC). The cumulative growth of the chicken body weight and size were analyzed with 3 mathematical models.
View Article and Find Full Text PDFFluor-Predictor: An Interpretable Tool for Multiproperty Prediction and Retrieval of Fluorescent Dyes.
J Chem Inf Model
March 2025
Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.
With the rapid advancements in the field of fluorescent dyes, accurate prediction of optical properties and efficient retrieval of dye-related data are essential for effective dye design. However, there is a lack of tools for comprehensive data integration and convenient data retrieval. Moreover, existing prediction models mainly focus on a single property of fluorescent dyes and fail to account for the diverse fluorophores and solutions in a systematic manner.
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