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Predicting human olfactory perception by odorant structure and receptor activation profile.
Chem Senses
January 2025
Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.
Humans possess a remarkable ability to discriminate a wide range of odors with high precision. This process begins with olfactory receptors (ORs) detecting and responding to the molecular structures of odorants. Recent studies have aimed to associate the activity of a single OR to an odor descriptor or predict odor descriptors using 2D molecular representation.
View Article and Find Full Text PDFNatural variation in CTF1 conferring cold tolerance at the flowering stage in rice.
Plant Biotechnol J
January 2025
Rice Research Institute, Key Laboratory of Genetics and Breeding of High Quality Rice in Southern China (Co-construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Guangdong Key Laboratory of New Technology in Rice Breeding, Guangdong Rice Engineering Laboratory, Guangdong Academy of Agricultural Sciences, Guangzhou, China.
Improving cold tolerance at the flowering stage (CTF) in rice is crucial for minimising yield loss, making the identification and application of cold-tolerant genes and QTLs imperative for effective molecular breeding. The long lead time, dependence on cold treatment conditions, and the inherent complexity of the trait make studying the genetic basis of CTF in rice challenging. To date, the fine-mapping or cloning of QTLs specific to CTF has not yet been achieved.
View Article and Find Full Text PDFSurfactant-Free Stable Aqueous Shortwave Infrared Amphiphilic π-Conjugated Polymer Nanoparticles.
Macromol Rapid Commun
January 2025
Institute of Chemical Biology, National Hellenic Research Foundation, 48 Vassileos Constantinou Avenue, Athens, 11635, Greece.
Novel amphiphilic π-conjugated polymer nanoparticles tailored to efficiently absorb in the near-infrared II (NIR-II) region of the electromagnetic spectrum (>1000 nm) are presented. To achieve this, it is statistically introduced triethylene glycol substituted bithiophene moieties in various contents into a polymer backbone consisting of alternating thiophene and [1,2,5]thiadiazolo[3,4-g]quinoxaline. Through systematic modifications of monomer ratios, four amphiphilic conjugated polymers are produced.
View Article and Find Full Text PDFQuantitative Enhancement of Arsenate Immobilization Induced by Vacancy Defects on Various Exposed Lattice Facets of Hematite.
Environ Sci Technol
January 2025
Geomicrobiology, Department of Geosciences, University of Tübingen, Tübingen 72076, Germany.
Defects are common features in hematite that arise from deviations from the perfect mineral crystal structure. Vacancy defects have been shown to significantly enhance arsenate (As) immobilization by hematite. However, the contributions from vacancy defects on different exposed facets of hematite have not been fully quantified.
View Article and Find Full Text PDFDecoding the Molecular Basis of the Specificity of an Anti-sTn Antibody.
JACS Au
January 2025
UCIBIO-Applied Molecular Biosciences Unit, Department of Chemistry, NOVA School of Science and Technology, NOVA University Lisbon, 2829-516 Caparica, Portugal.
The mucin -glycan sialyl Tn antigen (sTn, Neu5Acα2-6GalNAcα1--Ser/Thr) is an antigen associated with different types of cancers, often linked with a higher risk of metastasis and poor prognosis. Despite efforts to develop anti-sTn antibodies with high specificity for diagnostics and immunotherapy, challenges in eliciting high-affinity antibodies for glycan structures have limited their effectiveness, leading to low titers and short protection durations. Experimental structural insights into anti-sTn antibody specificity are lacking, hindering their optimization for cancer cell recognition.
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