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Retrospective evaluation of mild encephalitis/encephalopathy with a reversible splenial lesion in children.
Pediatr Int
March 2025
Department of Pediatrics, The Second Hospital of Hebei Medical University, Hebei Medical University, Shijiazhuang, Hebei, China.
Background: Comprehensive documentation on consecutive years of mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) in children is lacking. This study aims to provide an in-depth analysis of the clinical profiles of MERS in children across different age groups, focusing on pathogens and recovery time.
Methods: In this retrospective study, 43 patients diagnosed with MERS were enrolled between December 2017 and November 2021.
FEN1-assisted LAMP for specific and multiplex detection of pathogens associated with community-acquired pneumonia.
Analyst
March 2025
Department of Laboratory Medicine, Key Laboratory of Clinical Laboratory Technology for Precision Medicine, School of Medical Technology and Engineering, Fujian Medical University, Fuzhou 350005, China.
Lower respiratory tract infections (LRITs), including community-acquired pneumonia (CAP), are the fifth leading cause of death worldwide over the last ten years, posing a serious threat to global healthcare. Conventional laboratory assays for detecting pathogens are hindered by complicated procedures, a long turnaround time and a lack of multiplex detection capabilities. In this study, a flap-endonuclease 1 (FEN1)-assisted loop-mediated isothermal amplification (LAMP) method was designed, and an assay based on this method was developed to identify three leading pathogens for CAP, namely, , and .
View Article and Find Full Text PDFDNAH9 variants in children with post-infectious bronchiolitis/bronchitis obliterans.
Orphanet J Rare Dis
March 2025
Department II of Respiratory Medicine, National Clinical Research Center for Respiratory Disease, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
Post-infectious bronchiolitis/bronchitis obliterans (PIBO) is a chronic irreversible obstructive lung disease that results in obstruction and/or obliteration of small airways. Previous reports have indicated that PCD-related gene mutations contribute to PIBO incidence. However, the relationship between DNAH9 variants and PIBO remains unclear.
View Article and Find Full Text PDFPathogen priming alters host transmission potential and predictors of transmissibility in a wild songbird species.
mSphere
March 2025
Department of Biological Sciences, Virginia Tech, Blacksburg, Virginia, USA.
Pathogen reinfections occur widely, but the extent to which reinfected hosts contribute to ongoing transmission is often unknown despite its implications for host-pathogen dynamics. House finches () acquire partial protection from initial exposure to the bacterial pathogen (MG), with hosts readily reinfected with homologous or heterologous strains on short timescales. However, the extent to which reinfected hosts contribute to MG transmission has not been tested.
View Article and Find Full Text PDFFrom Conventional Detection to Point-of-care Tests (POCT) Method for Pediatric Respiratory Infections Diagnosis: A Systematic Review.
Arch Iran Med
February 2025
Pediatric Infectious Diseases Research Center (PIDRC), Tehran University of Medical Sciences, Tehran, Iran.
Bacterial respiratory infections pose significant health risks to children, particularly infants susceptible to upper respiratory tract infections (URTIs). The COVID-19 pandemic has further exacerbated the prevalence of these infections, with pathogens such as and commonly implicated in pediatric cases. The critical need for accurate and timely detection of these bacterial agents has highlighted the importance of advanced diagnostic techniques, including multiplex real-time PCR, in clinical practice.
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