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Optimal cutoff values of intraoperative parathyroid hormone for predicting early and permanent hypoparathyroidism after total thyroidectomy.
Langenbecks Arch Surg
January 2025
Unidad de Cirugía Endocrina, Hospital Universitari de Bellvitge, C/ Feixa Llarga s/n, L'Hospitalet de Llobregat, Barcelona, E-0897, Spain.
Purpose: Measurement of intraoperative intact parathyroid hormone (ioPTH) levels is a reliable predictor of postsurgical hypocalcemia. We assessed the optimal cutoff values of ioPTH decline for predicting postoperative early and permanent hypoparathyroidism.
Methods: This was a retrospective study of a prospectively maintained database of patients undergoing thyroid surgery in a tertiary care hospital in L'Hospitalet de Llobregat (Barcelona, Spain).
α-Adrenoreceptor blocker phentolamine inhibits voltage-gated sodium channels via the local anaesthetic binding site.
Br J Pharmacol
January 2025
Institute of Neurophysiology, Uniklinik RWTH Aachen University, Aachen, Germany.
Background And Purpose: Phentolamine is a non-selective α-adrenoreceptor antagonist used to reverse local anaesthesia, for example, during dental procedures when a vasoconstrictor is co-applied. Phentolamine-mediated vasodilation leads to faster clearance of injected drugs. Previous electrophysiological studies hypothesized that phentolamine acts as a modulator of voltage-gated sodium channels, which could conflict with its indication as local anaesthetic reversal agent.
View Article and Find Full Text PDFConus medullaris termination: Assessing safety of spinal anesthesia in the L2-L3 interspace.
Acta Anaesthesiol Scand
March 2025
Department of Clinical Epidemiology and Biostatistics, Biostatistics Unit, St. Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada.
Background: Classic teaching is that spinal anesthesia is safe at or below the L2-L3 interspace. To evaluate this, we sought to determine the percentage of individuals with a conus medullaris termination (CMT) level at or below the L1-L2 interspace. Further, the relationship of CMT level to age, sex, body mass index (BMI), and spinal pathology was examined, as was the reliability of using Tuffier's line (TL) as an anatomical landmark.
View Article and Find Full Text PDFComparison of plasma concentration and sedative effect of sublingual and intranasal dexmedetomidine in children: A double-blind randomised controlled study.
Acta Anaesthesiol Scand
March 2025
Department of Anaesthesiology, Pain Medicine and Critical Care, All India Institute of Medical Sciences, New Delhi, Delhi, India.
Background: Pharmacokinetics and sedative effects of sublingual dexmedetomidine have not been established in children. The primary aim was to compare peak plasma concentration, time to reach peak plasma concentration and area under the curve with 2 μg/kg sublingual and intranasal dexmedetomidine. The secondary aims were to compare the depth of sedation, parental separation anxiety, mask acceptance, heart rate changes, analgesic requirements and recovery time with 2 μg/kg sublingual and intranasal dexmedetomidine in children.
View Article and Find Full Text PDFThe adverse effects with ibuprofen after major orthopedic surgeries: A protocol for the PERISAFE randomized clinical trial.
Acta Anaesthesiol Scand
March 2025
Centre for Anaesthesiological Research, Department of Anesthesiology, Zealand University Hospital, Køge, Denmark.
Introduction: Non-steroidal anti-inflammatory drugs (NSAIDs) are recommended for pain treatment after elective hip and knee arthroplasties. However, evidence regarding the incidence of adverse effects with short-term NSAID treatment following surgery is limited. We, therefore, aim to assess the adverse effects with an eight-day postoperative treatment with ibuprofen after elective hip and knee arthroplasties.
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