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Phase I Dose Volume Escalation of Rectally Administered PC-1005 to Assess Safety, Pharmacokinetics, and Antiviral Pharmacodynamics as a Multipurpose Prevention Technology (MTN-037).
J Acquir Immune Defic Syndr
December 2024
The Johns Hopkins University, Baltimore, MD.
Background: On demand, topical PrEP is desired by those preferring episodic, nonsystemic PrEP. PC-1005 gel (MIV-150, zinc, and carrageenan) exhibits in vitro antiviral HIV-1, human papillomavirus (HPV), and herpes simplex virus type 2 (HSV-2) activity, attractive for a multipurpose prevention technology candidate. We evaluated the safety, pharmacokinetics, and antiviral effect of rectally applied PC-1005.
View Article and Find Full Text PDFProperties of the major Zn-binding site of human alpha-fetoprotein, a potential foetal plasma zinc carrier.
Chem Commun (Camb)
January 2025
Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK.
The foetal plasma protein α-fetoprotein (AFP) harbours a high-affinity zinc binding site that is likely involved in transport and delivery of essential zinc during foetal development. Based on a recent electron microscopy structure of AFP and aided by biophysical studies on an AFP-derived peptide, we present a refined 5-coordinate model for this site.
View Article and Find Full Text PDFEffect of Cashew Nut Consumption on Biomarkers of Copper and Zinc Status in Adolescents with Obesity: A Randomized Controlled Trial.
Nutrients
December 2024
Health Sciences Center, Universidade Estadual do Ceará, Fortaleza 60714-903, Brazil.
Background: Children and adolescents with obesity have altered serum copper (Cu) and zinc (Zn) levels, which are associated with oxidative stress, inflammation, and health outcomes. The inclusion of cashew nuts in an adequate diet may provide health benefits and help improve the mineral status of individuals with obesity.
Objective: To evaluate the effects of cashew nut consumption on biomarkers of Cu and Zn status in adolescents with obesity.
Micronutrient Deficiencies in Heart Failure and Relationship with Exocrine Pancreatic Insufficiency.
Nutrients
December 2024
Department of Cardiology, University Medical Centre Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands.
Background: Micronutrient deficiencies are common and play a significant role in the prognosis of many chronic diseases, including heart failure (HF), but their prevalence in HF is not well known. As studies have traditionally focused on causes originating within the intestines, exocrine pancreatic insufficiency (EPI) has been overlooked as a potential contributor. The exocrine pancreas enables the absorption of various (fat-soluble) micronutrients and may be insufficient in HF.
View Article and Find Full Text PDFComparative efficacy of hydroxychloride and organic sources of zinc, copper, and manganese on hatching eggs, embryo and hatchlings attributes.
Poult Sci
December 2024
Department of Animal Bioscience, University of Guelph, Guelph, Ontario N1G 2W1, Canada. Electronic address:
The objective of this study was to evaluate the impact of feeding broiler breeders hydroxychloride and organic sources of zinc (Zn), copper (Cu), and manganese (Mn) on hatching eggs, embryo, and hatchlings attributes. A total of 408 female (♀) and 48 male (♂) Ross 708 broiler breeder were placed (17 ♀ and 2 ♂/pen). The pens were housed in two rooms (12 pens/room).
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