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Clozapine for Treatment-Resistant Disruptive Behaviors in Youths With Autism Spectrum Disorder Aged 10-17 Years: Protocol for an Open-Label Trial.
JMIR Res Protoc
January 2025
Graduate Program of Psychiatry and Behavioral Sciences, Department of Psychiatry, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.
Background: Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition emerging in early childhood, characterized by core features such as sociocommunicative deficits and repetitive, rigid behaviors, interests, and activities. In addition to these, disruptive behaviors (DB), including aggression, self-injury, and severe tantrums, are frequently observed in pediatric patients with ASD. The atypical antipsychotics risperidone and aripiprazole, currently the only Food and Drug Administration-approved treatments for severe DB in patients with ASD, often encounter therapeutic failure or intolerance.
View Article and Find Full Text PDFDevelopment of a non-invasive heart rate measurement method for sea turtles with dense keratinous scutes through effective electrode placement.
Front Physiol
January 2025
Atmosphere and Ocean Research Institute, The University of Tokyo, Kashiwa, Japan.
Article Synopsis
- Measuring the heart rate of sea turtles helps us understand their physiological adaptations, particularly focusing on the non-invasive ECG methods developed for loggerhead turtles.
- The study explored alternative electrode placements on the plastron of green sea turtles, finding successful ECG readings when the negative electrode was positioned near the neck.
- Results showed that resting heart rates averaged about 8.6 beats per minute, aligning with previous studies, and highlight the need for careful individual selection to improve measurement reliability.
Multimodal Pain Recognition in Postoperative Patients: Machine Learning Approach.
JMIR Form Res
January 2025
Department of Computer Science, University of California, Irvine, Irvine, CA, United States.
Background: Acute pain management is critical in postoperative care, especially in vulnerable patient populations that may be unable to self-report pain levels effectively. Current methods of pain assessment often rely on subjective patient reports or behavioral pain observation tools, which can lead to inconsistencies in pain management. Multimodal pain assessment, integrating physiological and behavioral data, presents an opportunity to create more objective and accurate pain measurement systems.
View Article and Find Full Text PDFComparative Electrocardiographic Analysis Between Physical Exercise Practitioners and Athletes: A Cross-Sectional Study.
Int J Environ Res Public Health
January 2025
Study Design and Scientific Writing Laboratory, Centro Universitario FMABC, Santo André 09060-870, SP, Brazil.
The trained heart adapts through geometric changes influenced by concentric and eccentric hypertrophy, depending on the predominance of the isometric or dynamic components of the exercise performed. Additionally, alterations in heart rhythm may occur due to increased vagal system activity. Cardiological evaluation with an electrocardiogram (ECG) aims to identify cardiac conditions that could temporarily or permanently disqualify an athlete from competition.
View Article and Find Full Text PDFElectrocardiographic Assessment of National-Level Triathletes: Sinus Bradycardia and Other Electrocardiographic Abnormalities.
Sports (Basel)
January 2025
Exercise and Sport Sciences Department, Metropolitan State University of Denver, Denver, CO 80204, USA.
Background: High-intensity endurance training induces specific cardiac adaptations, often observed through electrocardiographic (ECG) changes. This study investigated the prevalence of ECG abnormalities in national-level Australian triathletes compared to sedentary controls.
Methods: A cross-sectional observational study was conducted involving 22 triathletes and 7 sedentary controls.
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