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S100A8 regulates postoperative responses following tooth extraction in rats.
Odontology
January 2025
School of Stomatology, Shandong Second Medical University, Weifang, 261053, Shandong, China.
The reduction in alveolar ridge height and width after tooth extraction poses a substantial challenge for dental implant restoration. This study aimed to observe the roles of S100A8 in the inflammatory response and bone resorption following tooth extraction. Rat mandibular second molars were extracted.
View Article and Find Full Text PDF[Factors associated with spontaneous re-eruption of traumatically intruded permanent anterior teeth in children and adolescents].
Beijing Da Xue Xue Bao Yi Xue Ban
February 2025
Department of Pediatric Dentistry, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing 100081, China.
Objective: To analyze the factors related to spontaneous re-eruption after intruded injury in permanent anterior teeth in children and adolescents.
Methods: Clinical data from 5- to 17-year-old patients who sustained intrusive luxation of permanent anterior teeth and treated in the Department of Pedia-tric Dentistry of Peking University School and Hospital of Stomatology from June 2015 to August 2024 were reviewed. Information of age, gender, degree of intrusion, direction of intrusion, tooth development, concomitant injuries, luxation and post-osteoclastic eruption of the adjacent teeth were recorded.
Senescent Fibroblasts Drive FAP/OLN Imbalance Through mTOR Signaling to Exacerbate Inflammation and Bone Resorption in Periodontitis.
Adv Sci (Weinh)
December 2024
State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, 430079, China.
Fibroblast activation protein (FAP), predominantly expressed in activated fibroblasts, plays a key role in inflammatory bone diseases, but its role in periodontitis remains unclear. Accordingly, this study identified a positive association between FAP levels and periodontitis susceptibility using Mendelian randomization analysis. Human and mouse periodontitis tissues show elevated FAP and reduced osteolectin (OLN), an endogenous FAP inhibitor, indicating a FAP/OLN imbalance.
View Article and Find Full Text PDFTherapeutic potential of farnesoid X receptor agonists for modulating inflammation and periodontal regeneration.
Clin Oral Investig
December 2024
Department of Stomatology, Hangzhou First People's Hospital Affiliated to West Lake University, No. 261, Huansha Road, Shangcheng District, Hangzhou, Zhejiang, 310006, China.
Objectives: Inflammation and osteoclast activity are important in various diseases, including periodontitis and osteoporosis. Farnesoid X receptor (FXR) has been identified as a promising target for modulating these processes. This study delved into the impact of FXR agonists on inflammation and periodontal regeneration using periodontitis models.
View Article and Find Full Text PDFHS-Scavenging Hydrogel Alleviating Mitochondria Damage to Control Periodontitis.
J Dent Res
February 2025
Department of Periodontology & Tissue Engineering and Regeneration, School and Hospital of Stomatology, Shandong University, Jinan, Shandong, China.
HS, as a typical metabolite of periodontal pathogens, exhibits a clear positive correlation with the occurrence and development of periodontitis. HS at physiological concentrations can regulate many biological processes. However, excess HS in the periodontal pocket can trigger secretion of proinflammatory cytokines, cause oxidative stress, and result in mitochondrial damage and cell death in human gingival fibroblasts, exacerbating periodontitis development and periodontal tissue destruction.
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