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http://dx.doi.org/10.1002/hlca.660510411 | DOI Listing |
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August 2011
Laboratorium Badań Srodowiskowych, Katedra i Zakład Toksykologii, Uniwersytet Medyczny im. Karola Marcinkowskiego, Poznań.
Diabetes is considered a group of diseases with chronic hyperglycemia caused by various organ disorders, failure or damage as a common feature. Hyperglycemia exerts toxic effect on endothelium, promotes oxidative stress, inhibits bioavailability of nitrogen monoxide (NO) and leads to formation of advanced glycation end products. Moreover, hyperglycemia induces production of reactive oxygen specimens (ROS) through several distinct mechanisms, such as: glucose autoxydation activation of polyol (sorbitol-aldose reductase) pathway, non-enzymatic glycation and neutrophil granulocyte's stimulation.
View Article and Find Full Text PDFAnn Nutr Aliment
January 1981
In this comprehensive approach, inhibition of autoxidation of PUFA by SOD or other enzymes has been studied. The systems used were: 1) in miscible media in which enzyme, substrat, and peroxidation products are soluble; 2) in non-miscible media such as emulsions; 3) in heterogenous media containing subcellular fragments or whole blended tissue. Depending on experimental conditions, inhibition or activation of peroxidation by SOD can be observed in miscible systems.
View Article and Find Full Text PDFAnn Nutr Aliment
November 1977
Addition of great quantity of alpha-tocopherol to an aqueous solution containing linoleic acid dispersed with twen 20 conduce to an important augmentation of the rate of formation of linoleic hydroperoxides. In these particular conditions, alpha-tocopherol have a prooxidant effect. In the same time, alpha-tocopherol is rapidly transformed into tocopherylquinone and a dimer of alpha-tocopherol.
View Article and Find Full Text PDFC R Acad Hebd Seances Acad Sci D
December 1975
Linoleic acid in aqueous emulsion is spontaneously autoxidized and product hydroperoxides. In vitro the autoxidation of the cis-9, cis-12, octadecadienoic acid with DL-alpha-tocopherol, both emulsified in water, shows an important increase of the hydroperoxides. During this time the tocopherol quickly disappears.
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