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Newcastle Disease Vaccination Program in Broilers Using an Apathogenic Heat-Resistant Vaccine.
Arch Razi Inst
June 2024
Department of Clinical Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran.
Newcastle disease (ND) is among the most common and deadliest poultry diseases worldwide. Thermostable Newcastle disease virus (NDV) vaccines have been widely used to protect village chickens against ND due to their decreased dependence on cold chains for transport and storage. The NDV4 Heat-Resistant (NDV4HR) vaccine is an apathogenic, heat-resistant, live vaccine that can induce immunity in chickens.
View Article and Find Full Text PDFAutoimmune haemolytic anaemias.
Nat Rev Dis Primers
November 2024
Hematology Unit, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.
Adult autoimmune haemolytic anaemias (AIHAs) include different subtypes of a rare autoimmune disease in which autoantibodies targeting autoantigens expressed on the membrane of autologous red blood cells (RBCs) are produced, leading to their accelerated destruction. In the presence of haemolytic anaemia, the direct antiglobulin test is the cornerstone of AIHA diagnosis. AIHAs are classified according to the isotype and the thermal optimum of the autoantibody into warm (wAIHAs), cold and mixed AIHAs.
View Article and Find Full Text PDFSafety and Immunogenicity Study of a Bivalent Vaccine for Combined Prophylaxis of COVID-19 and Influenza in Non-Human Primates.
Vaccines (Basel)
September 2024
Institute of Experimental Medicine, Saint-Petersburg 197022, Russia.
Background: Influenza and SARS-CoV-2 viruses are two highly variable pathogens. We have developed a candidate bivalent live vaccine based on the strain of licensed A/Leningrad/17-based cold-adapted live attenuated influenza vaccine (LAIV) of H3N2 subtype, which expressed SARS-CoV-2 immunogenic T-cell epitopes. A cassette encoding fragments of S and N proteins of SARS-CoV-2 was inserted into the influenza NA gene using the P2A autocleavage site.
View Article and Find Full Text PDFA Newcastle disease live virus vaccine is safe and efficacious at various storage conditions.
Vet Ital
September 2024
Faculty of Livestock Business Management, University of Veterinary and Animal Sciences, Lahore, Pakistan.
Pure, potent and efficacious vaccines could help in the control of Newcastle disease (ND). The present study was designed to evaluate the thermo-stability of a live-attenuated ND virus vaccine containing the Mukteswar strain and to genetically characterize the seed virus. Moreover, the presence of extraneous agents (Fowl adenovirus, Mycoplasma, Salmonella Pullorum, and Salmonella Gallinarum) was assessed using polymerase chain reactions (PCR) optimized for detection in a panel.
View Article and Find Full Text PDFDevelopment of cashew-alginate microbeads and powdered dose forms: prospects for oral vaccine delivery in chickens.
J Immunoassay Immunochem
November 2024
School of Veterinary Medicine, Kwame Nkruma University of Science and Technology Kumasi, Kumasi, Ghana.
Article Synopsis
- Conventional oral vaccine delivery in poultry faces challenges like vaccine breakdown in the GI tract and the requirement for cold storage.
- The study explored the use of cashew-alginate microbeads, developed through ionotropic gelation and freeze-drying, to create a more stable and protective vaccine delivery system.
- Results showed that these microbeads maintained vaccine effectiveness for three months without cold storage, indicating their potential for improving oral vaccine delivery in chickens.
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