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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1387509 | PMC |
| http://dx.doi.org/10.1097/00000658-196810000-00019 | DOI Listing |
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Advancement of the Dragon Heart 7-Series for Pediatric Patients With Heart Failure.
Artif Organs
January 2025
BioCirc Research Laboratory, School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, Pennsylvania, USA.
Background: Safe and effective pediatric blood pumps continue to lag far behind those developed for adults. To address this growing unmet clinical need, we are developing a hybrid, continuous-flow, magnetically levitated, pediatric total artificial heart (TAH). Our hybrid TAH design, the Dragon Heart (DH), integrates both an axial flow and centrifugal flow blood pump within a single, compact housing.
View Article and Find Full Text PDFCFD-Based Hemolysis Study of Fontan Cavopulmonary Assist Device Using Kriging Surrogate Modeling.
Artif Organs
January 2025
Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Background: Predicting hemolysis numerically based on the power-law model using idealized coefficients obtained from simplified devices yields a large variability in hemolysis index predictions. A computational fluid dynamics (CFD)-based Kriging surrogate modeling approach, developed by Craven et al. at the US Food & Drug Administration (FDA), was applied to a Fontan cavopulmonary assist device (CPAD) to generate device-specific hemolysis power-law coefficients.
View Article and Find Full Text PDFA less-invasive left atrial assist device concept for diastolic heart failure: First in vitro and in vivo assessment.
JTCVS Open
October 2024
Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio.
Objective: A less-invasive left atrial assist device (LAADx) is a novel and implantable, extracardiac blood pump concept, intended for the treatment of diastolic heart failure, represented by heart failure with preserved ejection fraction.
Methods: A mixed-flow pump was used as the working LAADx model. Its performance was evaluated at 3 speeds, using an in vitro pulsatile mock circulatory loop, with a pneumatic pump that can simulate diastolic heart failure conditions by adjusting the diastolic drive pressure.
Improving the hemocompatibility of centrifugal mechanical circulatory support devices at low flow rates.
Artif Organs
February 2025
Department of Cardiovascular and Thoracic Surgery, Institute of Cardiology, Pitié Salpêtrière Hospital, Assistance Publique Hôpitaux de Paris (AP-HP), Sorbonne University, Paris, France.
Background: An innovative solution has been recently proposed for the treatment of heart failure with preserved ejection fraction (HFpEF), using a centrifugal mechanical circulatory support (MCS) device. We sought firstly to assess the hemocompatibility of the proposed device. HFpEF treatment requires the blood pump to operate at low blood flow rate (0.
View Article and Find Full Text PDFSeries Multiblood Pump Design With Dual Activation for Pediatric Patients With Heart Failure.
ASAIO J
September 2024
From the BioCirc Research Laboratory, School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, Pennsylvania.
The translational development of pediatric ventricular assist devices (VADs) lags years behind adult device options, negatively impacting pediatric patient outcomes. To address this need, we are developing a novel, series-flow, double-blood pump VAD that integrates an axial and centrifugal pump into a single device. The axial pump is used for initial circulatory assistance in younger patients; then, an internal activation mechanism triggers the centrifugal pump to activate in line with the axial pump, providing additional pressure and flow to match pediatric patient growth cycles.
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