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The leader proteinase of foot-and-mouth disease virus: Efficiency through exosites.
Virology
January 2025
Max Perutz Labs, Medical University of Vienna, Dept. of Medical Biochemistry, Dr. Bohr-Gasse 9/3, A-1030, Vienna, Austria. Electronic address:
Viruses were shown to encode proteinases in the 1970s. Initially, it was assumed that they would be only used for proteolytic processing of the viral proteins. Subsequent investigations showed that such proteinases could affect host metabolism to benefit viral replication.
View Article and Find Full Text PDF6-thioguanine inhibits EV71 replication by reducing BIRC3-mediated autophagy.
BMC Microbiol
January 2025
Center for Public Health Research, Medical School of Nanjing University, Nanjing, China.
Background: Enterovirus 71 (EV71) is one of the major causative agents of hand, foot, and mouth disease (HFMD), and can cause severe cerebral complications and even fatality in children younger than 5 years old. However, there is no specific medication for EV71 infection in clinical practice. Our previous studies had identified the 6-thioguanine (6-TG), an FDA-approved anticancer drug, as a potential antiviral agent, but its anti-EV71 activity is largely unknown, therefore, we aim to explore the antiviral effect of 6-TG on EV71.
View Article and Find Full Text PDFNeutralizing antibody landscape of the non-polio Enteroviruses and future strategy.
Front Immunol
January 2025
Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, China.
The non-polio Enteroviruses (NPEVs), consist of enteroviruses, coxsackieviruses, echoviruses, and rhinoviruses, are causative agents for a wide variety of diseases, ranging from common cold to encephalitis and acute flaccid paralysis (AFP). In recent years, several NPEVs have become serious public health threats, include EV-A71, which has caused epidemics of hand-foot-and-mouth disease (HMFD) in Southeast Asia, and EV-D68, which caused outbreaks of severe respiratory disease in children worldwide. Infections with these viruses are associated with neurological diseases like aseptic meningitis and AFP.
View Article and Find Full Text PDFHand, foot and mouth disease (HFMD) is a major public health issue in Hubei Province; however, research on the direct and indirect effects of factors affecting HFMD is limited. This study employed structural equation modeling (SEM) and geographically weighted regression (GWR) to investigate the various impacts and spatial variations in the factors influencing the HFMD epidemic in Hubei Province from 2016 to 2018. The results indicated that (1) with respect to the direct effects, the number of primary school students had the greatest positive direct effect on the number of HFMD cases, with a coefficient of 0.
View Article and Find Full Text PDFA serosurvey study of hand, foot and mouth disease in healthy children aged 6 to 71 months old in West Bandung and Bandung Region, Indonesia.
BMC Infect Dis
January 2025
Public Health Department, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia.
Background: Hand, foot, and mouth disease (HFMD) is an infectious disease that often affects children under 5 years of age. Over the past 20 years, enterovirus 71 (EV71) has become a major concern among children, especially in the Asia-Pacific region. Currently, there are no data showing the seroprevalence of HMFDs in Indonesia.
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