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Reducing the Formation of Toxic Byproducts During the Photochemical Release of Epinephrine.
J Xenobiot
January 2025
Department of Physics, Novosibirsk State University, 630090 Novosibirsk, Russia.
Engineered light-sensitive molecules offer a sophisticated toolkit for the manipulation of biological systems with both spatial and temporal precision. Notably, artificial "caged" compounds can activate specific receptors solely in response to light exposure. However, the uncaging process can lead to the formation of potentially harmful byproducts.
View Article and Find Full Text PDFPreemptive hydromorphone analgesia reduces postoperative delirium and stress response in laparoscopic cholecystectomy patients.
Am J Transl Res
December 2024
Department of Anesthesiology, Xi'an Central Hospital No. 161, Xiwu Road, Xincheng District, Xi'an 710003, Shaanxi, China.
Objective: To evaluate the effects of preemptive hydromorphone analgesia on postoperative delirium and stress response in patients undergoing laparoscopic cholecystectomy.
Methods: A retrospective cohort study was conducted, including 167 patients who underwent laparoscopic cholecystectomy at Xi'an Central Hospital between June 2021 and November 2023. Patients were categorized into an observation group (n=87) receiving preemptive hydromorphone hydrochloride analgesia and a control group (n=80) without preemptive analgesia.
Senescence-like Phenotype After Chronic Exposure to Isoproterenol in Primary Quiescent Immune Cells.
Biomolecules
November 2024
Molecular Toxicology Group, Department of Biology, University of Konstanz, 78457 Konstanz, Germany.
Chronic stress is associated with a higher risk for carcinogenesis as well as age-related diseases and immune dysfunction. There is evidence showing that psychological stress can contribute to premature immunosenescence. Therefore, the question arose whether chronic exposure to catecholamine could drive immune cells into senescence.
View Article and Find Full Text PDFEffect of Clonidine on Duration of High-Volume, Low-Concentration Caudal Epidurals.
Cureus
December 2024
Anesthesiology and Perioperative Medicine, Medical University of South Carolina, Charleston, USA.
Article Synopsis
- Caudal blocks are a pediatric anesthesia technique used to manage pain after circumcision; this study aimed to compare the duration of the block when using a high-volume, low-concentration (HVLC) local anesthetic with and without the addition of clonidine.
- The study included 129 children aged 0-3 years and measured the effectiveness of pain relief based on how long patients waited before needing additional acetaminophen; no significant differences were found between the clonidine and no-clonidine groups regarding pain management or emergence agitation.
- Overall, the addition of clonidine did not significantly improve the outcomes of HVLC caudal blocks for children undergoing circumcision.
Fe-Co-Fe prussian blue analogues loaded nitrogen doped carbon quantum dots for effective epinephrine detection.
Talanta
January 2025
The School of Material Science and Chemical Engineering, Harbin University of Science and Technology, Harbin, 150040, PR China.
Epinephrine (Ep) is an important neurotransmitter, which plays an important role in the nervous system and glycogen metabolism of living organisms. Hence, a novel NCQDs/FeCoFe-PBA composite with FeCoFe-Prussian blue analogues (PBA) as the core and nitrogen-doped carbon quantum dots (NCQDs) as the shell was constructed by a one-pot hydrothermal method, and it was used for the efficient detection of Ep. As a good electroactive material, NCQDs in the composite not only improved the weak conductivity of FeCoFe-PBA, but also limited the self-aggregation of FeCoFe-PBA, and formed a uniform shell on FeCoFe-PBA.
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