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Sotalol poisoning and its unique treatment considerations compared with traditional therapies for beta-adrenoceptor blocking drug poisoning.
Clin Toxicol (Phila)
January 2025
Minnesota Regional Poison Center, Minneapolis, MN, USA.
Introduction: Sotalol is a beta-adrenoceptor blocking drug with unique physical and pharmacologic properties. Unlike most beta-adrenoceptor blocking drugs, sotalol is amenable to extracorporeal removal and causes QT interval prolongation and ventricular dysrhythmias. These properties have implications for treating sotalol poisoning.
View Article and Find Full Text PDFMasquerading details behind a murmur and chest pain.
Turk J Emerg Med
January 2025
University of Antioquia, Hospital Universitario San Vicente Fundacion, Medellin, Colombia.
Masquerading bundle branch block (MBBB) is a rare presentation of bifascicular blocks. It is the result of a right bundle branch block associated with an advanced left anterior fascicular block due to extensive damage to the conduction system. We present the case of a 75-year-old male with late onset presentation anterior wall myocardial infarction (MI) with ongoing ischemia (which evolved into a ventricular septal defect [VSD]).
View Article and Find Full Text PDFComplete atrial screw lead penetration and contralateral pneumothorax post-pacemaker implantation.
J Cardiol Cases
January 2025
Department of Cardiology, The Jikei University School of Medicine, Tokyo, Japan.
Unlabelled: There are some reports of atrial screw-in lead perforation, but the entire lead body is rarely exposed outside the right atrium at an early stage of the procedure. A man in his 80s had undergone catheter ablation for atrial fibrillation (AF) and had recurrent AF and tachycardia-bradycardia syndrome with 8.8 s of sinus arrest, which caused presyncope.
View Article and Find Full Text PDFDecoding dyspnoea: fluoroscopy of prosthetic valve dynamics in a young patient.
Heart
January 2025
Cardiology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, Puducherry, India
Subunit-specific conductance of single homomeric and heteromeric HCN pacemaker channels at femtosiemens resolution.
Proc Natl Acad Sci U S A
February 2025
Institut für Physiologie II, Universitätsklinikum Jena, Friedrich-Schiller-Universität Jena, Jena 07740, Germany.
In mammals, the four subunit isoforms HCN1-4 assemble to form functional homotetrameric and heterotetrameric hyperpolarization-activated cyclic nucleotide-modulated (HCN) ion channels. Despite the outstanding relevance of HCN channels for organisms, including generating electrical rhythmicity in cardiac pacemaker cells and diverse types of brain neurons, key channel properties are still elusive. In particular, the unitary conductance, of HCN channels is highly controversial.
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