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Caveolin-Mediated Endocytosis: Bacterial Pathogen Exploitation and Host-Pathogen Interaction.
Cells
December 2024
Molecular and Cellular Microbiology Laboratory, Department of Biological Sciences, Old Dominion University, Norfolk, VA 23529, USA.
Within mammalian cells, diverse endocytic mechanisms, including phagocytosis, pinocytosis, and receptor-mediated endocytosis, serve as gateways exploited by many bacterial pathogens and toxins. Among these, caveolae-mediated endocytosis is characterized by lipid-rich caveolae and dimeric caveolin proteins. Caveolae are specialized microdomains on cell surfaces that impact cell signaling.
View Article and Find Full Text PDFLemierre's Syndrome in a 16-Year-Old Man Associated with Resolution of Marked Widespread St Elevation and a Normal Troponin Level.
Eur J Case Rep Intern Med
December 2024
Respiratory Department, Barnsley District General Hospital, Barnsley, UK.
Unlabelled: A 16-year-old man presented to the Accident and Emergence services with a 10-day history of shortness of breath, sore throat, vomiting, diarrhoea, poor oral intake, chest pain, jaundice, diplopia and reduced urine output. He was initially treated for sepsis, however, subsequent imaging and blood cultures confirmed the diagnosis of Lemierre's syndrome (LS). LS, also known as necrobacillosis or post-pharyngitis anaerobic septicaemia is comprised of a triad of metastatic septic emboli secondary to pharyngitis, bacteraemia, and internal jugular vein thrombophlebitis.
View Article and Find Full Text PDFInfective endocarditis caused by - a retrospective registry-based study.
Infect Dis (Lond)
January 2025
Division of Infection Medicine, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.
Purpose: Infective endocarditis (IE) is diagnosed using the Duke criteria, which were updated in 2023. In the Duke-ISCVID 2023 criteria, was recognised as a typical IE pathogen. This study investigates the impact of this change and compares the clinical characteristics of IE to IE caused by other pathogens.
View Article and Find Full Text PDFInsights into Within-Host Evolution and Dynamics of Oral and Intestinal Streptococci Unveil Niche Adaptation.
Int J Mol Sci
December 2024
Division of Oral Microbiology and Immunology, Department of Operative Dentistry, Periodontology and Preventive Dentistry, Rheinisch-Westfälische Technische Hochschule (RWTH) University Hospital, 52074 Aachen, Germany.
The oral-gut axis is a complex system linking the oral cavity and gastrointestinal tract, impacting host health and microbial composition. This study investigates genetic changes and adaptive mechanisms employed by streptococci-one of the few genera capable of colonizing oral and intestinal niches-within the same individual. We conducted whole-genome sequencing (WGS) on 218 streptococcal isolates from saliva and fecal samples of 14 inflammatory bowel disease (IBD) patients and 12 healthy controls.
View Article and Find Full Text PDFOptimizing Biochar-Based Column Filtration Systems for Enhanced Pollutant Removal in Wastewater Treatment: A Preliminary Study.
Chemosphere
January 2025
Laboratory of Water, Biodiversity and Climate Change (EauBiodiCc), Faculty of Sciences Semlalia, University Cadi Ayyad, Marrakech Morocco; National Centre for Studies and Research on Water and Energy (CNEREE), University Cadi Ayyad, Marrakech Morocco. Electronic address:
Article Synopsis
- The study tests biochar-based substrates for their effectiveness in removing pollutants from wastewater, focusing on determining the best biochar concentration for large-scale filters like constructed wetlands.
- Preliminary lab tests using different concentrations of biochar (0%, 10%, 25%, and 50%) showed significant improvements in removing nitrogen, phosphorus, chemical oxygen demand, and total suspended solids in comparison to control filters.
- The best results for pollutant removal were achieved with 10% biochar, indicating that a lower concentration is both economically and environmentally beneficial for wastewater treatment systems.
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