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Resolution of oncogene-induced senescence markers in HPV-infected cervical cancer tissue.
BMC Cancer
January 2025
Department of Pharmacology and Public Health, Faculty of Medicine, The Hashemite University, Zarqa, 13133, Jordan.
Background: Oncogene-Induced Senescence (OIS) is a form of senescence that occurs as a consequence of oncogenic overstimulation and possibly infection by oncogenic viruses. Whether senescence plays a role in the pathogenesis of cervical cancer (CC) is not well understood. Moreover, whether cervical epithelial cells that are part of the premalignant cervical intraepithelial neoplasia (CIN), exhibit markers of OIS in Human Papillomavirus (HPV)-infected tissue, has not been investigated.
View Article and Find Full Text PDFImpact of normal vs. caesarean deliveries on child nutritional status and mortality in India: insights from NFHS-5 data.
BMC Pediatr
November 2024
P. G. Department of Geography, Fakir Mohan University, Balasore, Odisha, India.
Objective: Skilled birth attendance and place of delivery have a significant effect on child growth. The present paper examined the mode of delivery and its impact on child health among children 0-59 months in India.
Methods: A total of 200,794 samples were used in the study.
Prevalence of Primary Dysmenorrhea and Its Effect on the Quality of Life Among Female Students at Umm Al-Qura University.
Cureus
October 2024
Faculty of Medicine, Ibn Sina National College for Medical Studies, Jeddah, SAU.
Article Synopsis
- Primary dysmenorrhea is a prevalent menstrual disorder affecting 83.7% of female students at Umm Al-Qura University, causing considerable physical and emotional discomfort.
- The study found that 51.1% of participants experienced moderate pain, while 32.6% suffered from severe pain, with 75.5% reporting decreased productivity due to menstrual pain.
- The findings highlight the need for effective management strategies and greater awareness to improve the quality of life and academic performance of young women dealing with this condition.
Biochemical markers for prediction of the first half pregnancy losses: a review.
Rev Bras Ginecol Obstet
October 2024
Department of obstetrics and gynecology, West Kazakhstan Marat Ospanov Medical University Aktobe Kazakhstan Department of obstetrics and gynecology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan.
Article Synopsis
- About 26% of pregnancies end in miscarriage, with many cases remaining unexplained despite known causes like chromosomal abnormalities and uterine issues.
- A review of 27 studies involving over 134,000 patients examined various biochemical factors potentially linked to early pregnancy loss.
- Current research suggests there is no definitive biochemical marker for predicting first-trimester pregnancy losses, highlighting the need for combined indicators or new assessment models like α-fetoprotein in vaginal blood.
Background Pregnant women with primary Sjogren's syndrome (PSS) have a high incidence of maternal and fetal complications due to immunological variations caused by maternal antibodies (anti-Sjogren's-syndrome-related antigen A (SSA) and anti-anti-Sjogren's-syndrome-related antigen B (SSB) crossing the placenta from the 12th week of gestation, mediating the tissue damage. A multidisciplinary approach is required in the management of such patients. Data regarding the effects of PSS on pregnancy are deficient in the Indian context.
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