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Typical Atrial Flutter: A Practical Review.

J Cardiovasc Electrophysiol

January 2025

Cardiology Division, Geneva University Hospitals, Geneva, Switzerland.

Typical atrial flutter (AFL), defined as cavotricuspid isthmus (CTI)-dependent macro-re-entrant atrial tachycardia, often causes debilitating symptoms, and is associated with increased incidence of atrial fibrillation, stroke, heart failure, and death. Typical AFL occurs in patients with atrial remodeling and shares risk factors with atrial fibrillation. It is also common in patients with a history of prior heart surgery or catheter ablation.

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Purpose: Psychopharmacology prescriptions are complex, partly due to the complexity of the relationship between diagnosis and its etiology, as well as the iatrogenic impact on symptomatology. Many multidisciplinary tools exist to optimize their management and improve evidence-based practice. However, their multidisciplinary integration seems to be a challenge.

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Mapping genetic susceptibility to spontaneous preterm birth: analysis of Utah pedigrees to find inherited genetic factors.

Am J Obstet Gynecol

December 2024

Department of Obstetrics and Gynecology, University of Utah Health, Salt Lake City, UT; Intermountain Healthcare, Maternal-Fetal Medicine, Salt Lake City, UT.

Article Synopsis
  • Spontaneous preterm birth (SPTB) is a major cause of health issues in newborns and can arise from various unknown genetic factors, prompting the need for better understanding through family studies.
  • The research utilized the Utah Population Database to identify large families with multiple cases of early SPTB and focused on seven specific pedigrees for genetic analysis, excluding other known causes of preterm birth.
  • The study discovered two significant chromosomal regions related to SPTB, particularly in chromosome 8 (8q24.23), suggesting potential genetic markers for this condition.
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Introduction And Aims: Arterial pseudoaneurysm is a rare yet potentially life-threatening complication that can arise as a late sequelae of penetrating injuries or orthopaedic procedures. We aim at sharing our institutional experience of managing 18 cases of lower limb arterial pseudoaneurysms in orthopaedic practice and to provide technical tips for emergency management of severe bleeding. A comprehensive literature review resulting from fractures and orthopaedic surgeries is also presented.

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Functional pathology of neuroleptic-induced dystonia based on the striatal striosome-matrix dopamine system in humans.

J Neurol Neurosurg Psychiatry

December 2024

Research Organization of Science and Technology, Ritsumeikan University, Kyoto, Japan

Neuroleptic-induced dystonia is a source of great concern in clinical practice because of its iatrogenic nature which can potentially lead to life-threatening conditions. Since all neuroleptics (antipsychotics) share the ability to block the dopamine D-type receptors (DRs) that are highly enriched in the striatum, this drug-induced dystonia is thought to be caused by decreased striatal DR activity. However, how associations of striatal DR inactivation with dystonia are formed remains elusive.

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