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Heparin Resistance in Patients Receiving Extracorporeal Membrane Oxygenation: A Review.
J Clin Med
December 2024
Department of Surgery, Nazarbayev University School of Medicine, Astana 010000, Kazakhstan.
Heparin resistance (HR) in patients on extracorporeal membrane oxygenation (ECMO) exacerbates bleeding and thrombogenesis. Thus far, there is no universal definition of what this condition entails and no unified strategy for assessing heparin's efficacy in ECMO patients. The most frequent discrepancy when it comes to defining HR is the difference in the reported doses: units per day (U/d) or per kilogram per hour (U/kg/h).
View Article and Find Full Text PDFProteomics Analysis of Five Potential Plasma-derived Exosomal Biomarkers for Acute Myocardial Infarction.
Curr Med Chem
January 2025
Department of Cardiology, Taizhou Hospital of Zhejiang Province, affiliated to Wenzhou Medical University, Linhai, Zhejiang Province, China.
Aims: This study was to explore the relationship between plasma exosomes and Acute myocardial infarction (AMI).
Background: Acute myocardial infarction (AMI) is one of the most common cardiovascular complications. Recent studies have shown that exosomes play a crucial role in the development and progression of cardiovascular diseases.
Post-Translational Modifications Control Phase Transitions of Tau.
ACS Cent Sci
November 2024
Department of Chemistry, University of Colorado, Boulder, Boulder, Colorado 80309, United States.
Article Synopsis
- * Researchers synthesized a Tau segment with various PTMs and observed that these modifications generally hinder Tau's assembly into PHFs, with acetylation showing variable effects, and phosphorylation consistently reducing aggregation.
- * The findings emphasize that PTMs located outside the rigid core of Tau filaments are crucial for initiating PHF formation, illustrating the complex role of these modifications in influencing Tau aggregation dynamics.
A collaborative study to establish the second national standard for antithrombin concentrate in Korea.
Biologicals
February 2025
Blood Products Division, Biopharmaceuticals & Herbal Medicine Evaluation Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Cheongju-si, South Korea. Electronic address:
This study aimed to establish a second national standard for antithrombin (AT) concentrate that can be used for potency assays of AT products. A collaborative study was conducted involving four laboratories, including national control laboratories and manufacturers in Korea, and the suitability of a candidate material to serve as the second national standard for AT concentrate was evaluated. The candidate material was manufactured using a process approved for Good Manufacturing Practices.
View Article and Find Full Text PDFStructural analysis of the stable form of fibroblast growth factor 2 - FGF2-STAB.
J Struct Biol X
December 2024
Loschmidt Laboratories, Department of Experimental Biology and RECETOX, Faculty of Science, Masaryk University, Brno, Czech Republic.
Fibroblast growth factor 2 (FGF2) is a signaling protein that plays a significant role in tissue development and repair. FGF2 binds to fibroblast growth factor receptors (FGFRs) alongside its co-factor heparin, which protects FGF2 from degradation. The binding between FGF2 and FGFRs induces intracellular signaling pathways such as RAS-MAPK, PI3K-AKT, and STAT.
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