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Heatstroke characteristics and meteorological conditions in Hefei, China: thresholds and driving factors.
BMC Public Health
January 2025
Key Laboratory of Cities Mitigation and Adaptation to Climate Change in Shanghai (CMACC), Shanghai, 200092, China.
Background: Due to climate change and rapid urbanization, the frequency of heatwave events in East China has increased considerably since the 21st century, which has a considerable influence on human health, such as heatstroke. However, few studies have been conducted in this region on the relationship between heatstroke and meteorological conditions. To address this point, this study aimed to analyze the characteristics of heatstroke and their relationship with meteorological conditions in Hefei, China.
View Article and Find Full Text PDFCotadutide reversible self-assembly based long-acting injectable depot for sustained delivery of GLP-1 glucagon receptor agonists with controlled burst release.
J Control Release
January 2025
Advanced Drug Delivery, Pharmaceutical Sciences, R&D, AstraZeneca, Waltham, MA, USA.
Cota is a lipidated dual GLP-1 and Glucagon receptor agonist that was investigated for the treatment of various metabolic diseases, it is designed for once daily subcutaneous administration. Invasive daily injections often result in poor patient compliance with chronic disease, and here, we demonstrate an innovative strategy of encapsulating reversible cota self-assembled fibers within an in-situ forming depot of low molecular weight poly(lactic-co-glycolic) acid (LWPLGA) for sustained delivery GLP-1 and Glucagon receptor agonist with controlled burst release. This could be a suitable alternative to other sustained delivery strategies for fibrillating peptides.
View Article and Find Full Text PDFObjective: This study aims to characterize concurrent nasal symptoms in a cohort of patients with non-rhinogenic headache (NRH) presenting to an otolaryngology clinic.
Study Design: A prospective cohort.
Setting: Single tertiary care institution.
The use of an automatic remote weight management system to track treatment response, identified drugs supply shortage and its consequences: A pilot study.
Digit Health
January 2025
Ohad Cohen Endocrinology, Tel Hashomer, Israel.
Objective: The objective of this pilot study is to evaluate the feasibility of using an automatic weight management system to follow patients' response to weight reduction medications and to identify early deviations from weight trajectories.
Methods: The pilot study involved 11 participants using Semaglutide for weight management, monitored over a 12-month period. A cloud-based, Wi-Fi-enabled remote weight management system collected and analyzed daily weight data from smart scales.
Theabrownin remodels the circadian rhythm disorder of intestinal microbiota induced by a high-fat diet to alleviate obesity in mice.
Food Funct
January 2025
College of Food Science and Technology, Yunnan Agricultural University, Kunming, 650201, China.
The intestinal microbiota undergoes diurnal compositional and functional oscillations within a day, which affect the metabolic homeostasis of the host and exacerbate the occurrence of obesity. TB has the effect of reducing body weight and lipid accumulation, but the mechanism of improving obesity caused by a high-fat diet based on the circadian rhythm of intestinal microorganisms has not been clarified. In this study, we used multi-omics and imaging approaches to investigate the mechanism of TB in alleviating obesity in mice based on the circadian rhythm of gut microbiota.
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