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Optoacoustic microscopy (OAM) can image intrinsic optical absorption contrast at depths of several millimeters where state-of-the-art optical microscopy techniques fail due to intense light scattering in living tissues. Yet, wide adoption of OAM in biology and medicine is hindered by slow image acquisition speed, small field of view (FOV), and/or lack of spectral differentiation capacity of common system implementations. We report on a rapid acquisition functional optoacoustic micro-angiography approach that employs a burst-mode laser triggering scheme to simultaneously acquire multi-wavelength 3D images over an extended FOV covering ${50}\;{\rm mm} \times {50}\;{\rm mm}$50mm×50mm in a single mechanical overfly scan, attaining 28 µm and 14 µm resolution in lateral and axial dimensions, respectively.
View Article and Find Full Text PDFNeo-Angiogenesis, Transplant Viability, and Molecular Analyses of Vascularized Bone Allotransplantation Surgery in a Large Animal Model.
J Orthop Res
February 2020
Department of Orthopedic Surgery, Microvascular Research Laboratory, Mayo Clinic, 200 1st street SW55905, Building: MS-3-85, Rochester, Minnesota.
Vascularized composite allotransplantation of bone is a possible alternative treatment for large osseous defects but requires life-long immunosuppression. Surgical induction of autogenous neo-angiogenic circulation maintains transplant viability without this requirement, providing encouraging results in small animal models [1-3]. A preliminary feasibility study in a swine tibia model demonstrated similar findings [4, 5].
View Article and Find Full Text PDFQuantitative comparison using Generalized Relative Object Detectability (G-ROD) metrics of an amorphous selenium detector with high resolution Microangiographic Fluoroscopes (MAF) and standard flat panel detectors (FPD).
Proc SPIE Int Soc Opt Eng
February 2016
Toshiba Stroke and Vascular Research Center, University at Buffalo, Buffalo, NY.
A novel amorphous selenium (a-Se) direct detector with CMOS readout has been designed, and relative detector performance investigated. The detector features include a 25m pixel pitch, and 1000m thick a-Se layer operating at 10V/m bias field. A simulated detector DQE was determined, and used in comparative calculations of the Relative Object Detectability (ROD) family of prewhitening matched-filter (PWMF) observer and non-prewhitening matched filter (NPWMF) observer model metrics to gauge a-Se detector performance against existing high resolution micro-angiographic fluoroscopic (MAF) detectors and a standard flat panel detector (FPD).
View Article and Find Full Text PDFNew Family of Generalized Metrics for Comparative Imaging System Evaluation.
Proc SPIE Int Soc Opt Eng
February 2015
Toshiba Stroke and Vascular Research Center, University at Buffalo, Buffalo, NY.
A family of imaging task-specific metrics designated Relative Object Detectability (ROD) metrics was developed to enable objective, quantitative comparisons of different x-ray systems. Previously, ROD was defined as the integral over spatial frequencies of the Fourier Transform of the object function, weighted by the detector DQE for one detector, divided by the comparable integral for another detector. When effects of scatter and focal spot unsharpness are included, the generalized metric, GDQE, is substituted for the DQE, resulting in the G-ROD metric.
View Article and Find Full Text PDFWorkflow for the use of a high-resolution image detector in endovascular interventional procedures.
Proc SPIE Int Soc Opt Eng
March 2014
Toshiba Stroke and Vascular Research Center, University at Buffalo, Buffalo, NY 14214.
Endovascular image-guided intervention (EIGI) has become the primary interventional therapy for the most widespread vascular diseases. These procedures involve the insertion of a catheter into the femoral artery, which is then threaded under fluoroscopic guidance to the site of the pathology to be treated. Flat Panel Detectors (FPDs) are normally used for EIGIs; however, once the catheter is guided to the pathological site, high-resolution imaging capabilities can be used for accurately guiding a successful endovascular treatment.
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