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Boldine prevents the inflammatory response of cardiac fibroblasts induced by SGK1-NFκB signaling pathway activation.
Cell Signal
August 2024
Biomedical Science Institute, Faculty of Medicine, University of Chile, Santiago, Chile; Department of Pharmacological & Toxicological Chemistry, Faculty of Chemical & Pharmaceutical Sciences & Faculty of Medicine, University of Chile, Santiago, Chile. Electronic address:
Cardiac fibroblasts (CF) are mesenchymal-type cells responsible for maintaining the homeostasis of the heart's extracellular matrix (ECM). Their dysfunction leads to excessive secretion of ECM proteins, tissue stiffening, impaired nutrient and oxygen exchange, and electrical abnormalities in the heart. Additionally, CF act as sentinel cells in the cardiac tissue microenvironment, responding to various stimuli that may affect heart function.
View Article and Find Full Text PDFBoldine protects against carbon tetrachloride-induced chronic liver injury by regulating NF-κB signaling pathway.
J Biochem Mol Toxicol
April 2024
Department of Anatomy, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Chennai, India.
Sustained liver injuries predominantly promote oxidative stress and inflammation that lead to the progression of chronic liver disease (CLD), including fibrosis, cirrhosis, and hepatocellular carcinoma. Boldine, an alkaloid isolated from Peumus boldus, has been shown to have antioxidant and anti-inflammatory effects. Currently, there is no definitive treatment option available for CLD.
View Article and Find Full Text PDFToward a More Sustainable Sample Preparation in Phytochemistry: Case Studies in Four Subclasses of Alkaloids.
J Nat Prod
March 2024
Green Biotech Network, School of Agricultural Sciences, São Paulo State University (UNESP), 18610-034 Botucatu, Brazil.
The fact that alkaloids are bases has been the most explored chemical feature of their extraction and purification procedures. The main drawback of these procedures is that they employ undesirable chemicals, with HCl and CHCl probably being the most commonly employed chemicals in their subsequent steps. This work tested the hypothesis that advantages in recovery efficiency support this common practice.
View Article and Find Full Text PDFGall inducer Dasineura sp. alters the polyphenol profile and antioxidant activity of Peumus boldus stems.
Tree Physiol
February 2024
Laboratorio de Semioquímica Aplicada, Facultad de Ciencias Forestales, Universidad de Concepción, Concepción, Chile, Casilla 160-C, 4030000 Concepción, Chile.
Peumus boldus, a tree native to Chile, is extensively used for medicinal purposes due to its richness in alkaloids and antioxidant polyphenols. A species of galling insect, Dasineura sp. induces structural and chemical changes on P.
View Article and Find Full Text PDFBoldine: a narrative review of the bioactive compound with versatile biological and pharmacological potential.
J Complement Integr Med
January 2024
Central Council for Research in Ayurvedic Sciences, Janakpuri, New Delhi, India.
Objective: Boldine is a plant-derived bioactive compound that has a beneficial impact on human health. Boldine is an aporphine alkaloid mainly obtained from the leaves and bark of the Chilean Boldo tree (, Family: Monimiaceae). There are plenty of preclinical evidence supports that boldine exerts its beneficial effects against various diseases.
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