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Influence of accelerated arterial aging in growth-restricted cohorts on adult-onset cardiovascular diseases.
Am J Physiol Heart Circ Physiol
July 2023
Emeritus Head, Paediatric and Fetal Cardiac Units, Monash Health, Melbourne, Victoria, Australia.
Epidemiologists have long documented a higher risk of adult-onset cardiovascular diseases (CVDs) such as stroke, hypertension, and coronary artery disease, as well as mortality from circulatory causes in low birth-weight cohorts (poor in utero substrate supply). Utero-placental insufficiency and in utero hypoxemic state-induced alterations in arterial structure and compliance are important initiating factors for adult-onset hypertension. The mechanistic links between fetal growth restriction and CVD include decreased arterial wall elastin-to-collagen ratio, endothelial dysfunction, and heightened renin-angiotensin-aldosterone system (RAAS).
View Article and Find Full Text PDFArticle Synopsis
- - Hypertensive disorders of pregnancy (HDP) pose significant risks for both mothers and babies, leading to increased maternal and fetal health problems, and those affected are at higher risk for cardiovascular diseases later in life.
- - Current diagnosis and treatment guidelines for HDP in the U.S. have seen little change over the years, primarily due to concerns about the effects of blood pressure treatment on fetal health and the uncertainty of benefits from normalizing blood pressure.
- - The report emphasizes the need for updated guidelines, supports the potential benefits of adjusting blood pressure treatment goals during pregnancy, and highlights the importance of understanding socioeconomic and biological factors to address racial and ethnic disparities in maternal healthcare.
Utero-placental apoplexy during induction of therapeutic abortion in a 18-week pregnancy.
Eur Rev Med Pharmacol Sci
July 2021
Department of Gynecology and Obstetrics - University of L'Aquila (Italy), Medical School, University of L'Aquila, L'Aquila, Italy.
Utero-Placental Apoplexy, or Couvelaire Uterus, is a third-trimester major obstetrical complication, occurring especially during labor. It consists of placental abruption followed by an acute intradecidual hemorrhage produced by the rupture of the uterus-placental spiral arterioles leading to a retroplacental hematoma. This hemorrhage infiltrates the uterine wall up to intra- and retro-peritoneal areas.
View Article and Find Full Text PDFThe predictive value of pre-delivery laboratory test results for the severity of placental abruption and pregnancy outcome.
Placenta
January 2021
Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei, China; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University), Hefei, China; Anhui Province Key Laboratory of Reproductive Health and Genetics, Hefei, Anhui, China. Electronic address:
Introduction: To analyze the relationship between placental abruption severity and maternal pregnancy outcome and to explore the predictive value of pre-delivery laboratory test results for the severity of placental abruption.
Methods: The clinical datas of 126 patients with placental abruption diagnosed and treated in our hospital over the past 4 years were retrospectively analyzed. The severity of placental abruption was divided into degrees I to III.
The Cerebral Hemodynamic Response to Pain in Preterm Infants With Fetal Growth Restriction.
Front Pediatr
May 2020
Department of Paediatrics, The Ritchie Centre, Hudson Institute of Medical Research, Monash University, Melbourne, VIC, Australia.
Preterm infants undergoing intensive care often experience painful procedures such as heel lance for blood sampling. Knowledge of the cerebral hemodynamic response to painful stimuli contributes to understanding of cortical pain processing and the neurovascular network in the preterm brain. Previous research has demonstrated cerebral hemodynamic responses using near-infrared spectroscopy (NIRS) after noxious stimuli in infants appropriately grown for age (AGA).
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