Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s0368-1319(68)80101-2 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The effects produced by the two pyrimidine derivatives pyridinol carbamate (parmidine) and xymedon on cholesterol metabolism and experimental atherosclerosis were comparatively studied in rabbits. The rabbits were fed either a chow containing cholesterol (200 mg/kg body weight) or the same diet also containing xymedon (30 mg/kg body weight) or pyridinol carbamate (30 mg/kg body weight). Total plasma cholesterol showed 5.
View Article and Find Full Text PDFWe've studied xymedon (30 mg/kg, 12 m) and parmidin (pyridinolcarbamate 30 mg/kg, 12 m.) effects on the development of experimental cholesterol atherosclerosis on rabbits. It was demonstrated that after the use of xymedon aorta damage reduces twice.
View Article and Find Full Text PDFA sesquiterpenic lactone leucomyzin possessing the anti-inflammatory activity significantly reduces the extensiveness of atherosclerotic lesions of the aortas of the rabbits receiving dietary cholesterol. The drug prevents an increase of permeability of the aorta and microvessels under the influence of cholesterol, bradykinin, ovalbumin and histamine. In addition to the angioprotective action, leucomyzin possesses the hypolipidemic activity in rats with experimental hyperlipidemias and (after prolonged administration) in rabbits with cholesterol atherosclerosis.
View Article and Find Full Text PDFPreparation and evaluation of the antiatherosclerotic activity of unsymmetrical pyridinolcarbamates.
Tokyo Ika Shika Daigaku Iyo Kizai Kenkyusho Hokoku
May 1991
To discover a new and powerful antiathersclerotic agent which can regulate the transendotherial infiltration of very low density lipoprotein (VLDL), LDL, and another type of atherogenics, various kinds of unsymmetrical pyridinolcarbamate derivatives were prepared. The syntheses were started from partial reduction of diethyl dipicolinate with sodium borohydride. The resulted hydroxymethyl group was converted to N-methylcarbamate by a general procedure, and the remaining 6-ethoxycarbonyl group was modified to various kinds of structures.
View Article and Find Full Text PDFChronic administration of methionine to rats induced endothelial lesion manifested by increased endothelaemia and metabolic changes indicative of pathological processes involving the vessel wall. These changes did not spontaneously return to values observed in control animals. Long-term administration of antiatherosclerotic drugs Pyridinolcarbamate and Phtalazinole II normalized metabolic disorder in the aortic wall and reduced endothelaemia to normal values.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!