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Fertility-preserving treatment for stage IA endometrial cancer: a systematic review and meta-analysis.
Am J Obstet Gynecol
December 2024
Department of Obstetrics and Gynecology, Columbia University College of Physicians and Surgeons, New York, NY; Herbert Irving Comprehensive Cancer Center, New York, NY; Department of Obstetrics and Gynecology, New York Presbyterian Hospital, New York, NY. Electronic address:
Article Synopsis
- A systematic review and meta-analysis were conducted to evaluate the effectiveness of oral progestins and levonorgestrel-releasing intrauterine devices (LNG-IUD) in treating reproductive-aged patients with early-stage endometrial cancer.
- The study analyzed data from 754 patients, focusing on the complete response rates within one year for both treatment methods.
- Results indicated that both progestin therapies showed promise in effectively treating early-stage endometrial cancer, with specific outcomes assessed for each treatment type.*
[Bariatric surgery and drugs: Review of the literature and Adverse Drug Reactions analysis in French National Pharmacovigilance Database].
Therapie
October 2024
Service de pharmacologie médicale, centre de pharmacovigilance de Toulouse, CIC1436, faculté de médecine, CHU de Toulouse, 31000 Toulouse, France. Electronic address:
Introduction: Bariatric surgery is the only treatment for severe obesity (BMI>35kg/m) currently recognized as effective both in achieving tangible and lasting weight loss, and in improving obesity-related comorbidities such as type 2 diabetes, hypertension, and cardiovascular complications. Bariatric surgery, like any other surgery of the digestive tract, can have an impact on nutrient absorption, as well as on drug absorption. The literature on drug management in bariatric surgery patients concerned mainly of case reports and retrospective studies involving a small number of patients.
View Article and Find Full Text PDFA review of the pharmacology, clinical outcomes, and real-world effectiveness, safety, and non-contraceptive effects of NOMAC/E2.
Eur J Obstet Gynecol Reprod Biol X
March 2024
Theramex HQ UK Ltd, 50 Broadway, 5th Floor, London SW1H 0BL, UK.
Article Synopsis
- * Nomegestrol acetate + 17β-estradiol (NOMAC/E2) is a combined oral contraceptive that effectively inhibits ovulation and has unique characteristics, as outlined in clinical and real-world studies.
- * The review discusses NOMAC/E2's pharmacological effects, clinical efficacy, safety data, and non-contraceptive benefits, finding it has a long half-life, effective pregnancy prevention, and low risk for serious safety issues like venous thromboembolism.
Background: We conducted a systematic review and meta-analysis to examine outcomes of patients with endometrial intraepithelial neoplasia treated with oral progestins or a levonorgestrel-releasing intrauterine device (IUD).
Methods: We conducted a systematic review across 5 databases to examine outcomes of progestational treatment (oral progestins or levonorgestrel-releasing IUD) for patients with endometrial intraepithelial neoplasia. The primary outcome was the best complete response rate within 12 months of primary progestational treatment.
The link between daily affective complexity and anxiety is altered by oral contraceptive use.
Int J Psychophysiol
April 2024
University of Michigan, Department of Psychology, USA. Electronic address:
Affective complexity - the unique ways in which individuals' emotions covary and differentiate - is an important aspect of internalizing problems. For instance, daily affective complexity has been linked to anxiety increases in women and to decreases in men. The mechanisms underlying this gender difference have not been widely investigated, but a role for ovarian hormones is likely.
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