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Novel Pharmacologic Treatments of Female Sexual Dysfunction.
Clin Obstet Gynecol
March 2025
Department of Psychiatry & Neurobehavioral Sciences.
This review evaluates pharmacologic treatments for female sexual dysfunction (FSD), focusing on hypoactive sexual desire disorder (HSDD). We provide clinically relevant applications for Food and Drug Administration (FDA)-approved medications (flibanserin and bremelanotide) and investigational therapies (Lorexys and testosterone combinations). Detailed study outcomes, safety profiles, and clinical strategies guide clinicians in appropriate diagnosis, patient selection, expectation setting, side effect management, and patient education, improving treatment outcomes and patient satisfaction.
View Article and Find Full Text PDFIn vitro stretch modulates mitochondrial dynamics and energy metabolism to induce smooth muscle differentiation in mesenchymal stem cells.
FASEB J
January 2025
Key Laboratory of Biomechanics and Mechanobiology, Ministry of Education, Key Laboratory of Innovation and Transformation of Advanced Medical Devices, Ministry of Industry and Information Technology, National Medical Innovation Platform for Industry-Education Integration in Advanced Medical Devices (Interdiscipline of Medicine and Engineering), School of Biological Science and Medical Engineering, Beihang University, Beijing, China.
The smooth muscle cells (SMCs) located in the vascular media layer are continuously subjected to cyclic stretching perpendicular to the vessel wall and play a crucial role in vascular wall remodeling and blood pressure regulation. Mesenchymal stem cells (MSCs) are promising tools to differentiate into SMCs. Mechanical stretch loading offers an opportunity to guide the MSC-SMC differentiation and mechanical adaption for function regeneration of blood vessels.
View Article and Find Full Text PDFKAE ameliorates LPS-mediated acute lung injury by inhibiting PANoptosis through the intracellular DNA-cGAS-STING axis.
Front Pharmacol
January 2025
College of Pharmacy, Yanbian University Hospital, Yanbian University, Yanji, China.
Background: Acute lung injury (ALI) is a severe condition characterized by inflammation, tissue damage, and persistent activation of the cyclic GMP-AMP (cGAS)-stimulator of interferon genes (STING) pathway, which exacerbates the production of pro-inflammatory mediators and promotes the progression of ALI. Specific inhibition of this pathway has been shown to alleviate ALI symptoms. Kaempferol-3---L-(4″--p-coumaroyl)-rhamnoside (KAE), an active compound found in the flowers of Kitagawa, exhibits anti-inflammatory and antioxidant properties.
View Article and Find Full Text PDFTowards Improved Peptidic α-Ketoamide Inhibitors of the Plasmodial Subtilisin-Like SUB1: Exploration of N-Terminal Extensions and Cyclic Constraints.
ChemMedChem
January 2025
Université de Montpellier: Universite de Montpellier, IBMM, Pôle Chimie Balard, Campus CNRS, 34093, Montpellier, FRANCE.
After more than 15 years of decline, the Malaria epidemy has increased again since 2017, reinforcing the need to identify drug candidates active on new targets involved in at least two biological stages of the Plasmodium life cycle. The SUB1 protease, which is essential for parasite egress in both hepatic and blood stages, would meet these criteria. We previously reported the structure-activity relationship analysis of α-ketoamide-containing inhibitors encompassing positions P4-P2'.
View Article and Find Full Text PDFIn-vitro assay studies and molecular docking of functionalized chitosan decorated vanadium pentoxide nano-agents as an antidiabetic drug.
Int J Biol Macromol
January 2025
Dept. of Chemistry, Netaji Subhas University of Technology (N.S.U.T.), erstwhile N.S.I.T., Azad Hind Fauj Marg, Dwarka, Delhi 110078, India. Electronic address:
This study aims to enhance the antidiabetic potential of Vanadium pentoxide (VO) by synthesizing chitosan-based nanoparticles (NPs). Chitosan and its derivatives were used to fabricate VO NPs, ensuring enhanced antioxidant and antidiabetic activity. Surface topography was analyzed using atomic force microscopy (AFM), revealing bioactive sites on the NPs with improved electron-transfer capability, as confirmed by cyclic voltammetry (CV).
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