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Assessment of anti-cancer evaluation of new metabolites isolated from baked Sarcosphaera crassa: An edible poisonous mushroom.
Steroids
December 2024
Department of Chemistry, Faculty of Sciences, Muğla Sıtkı Koçman University, 48121 Kötekli, Muğla, Turkiye. Electronic address:
Article Synopsis
- Growing interest in wild mushrooms as functional foods has risen due to their health benefits, although Sarcosphaera crassa is a toxic mushroom consumed only after cooking, particularly in Europe.
- Baked Sarcosphaera crassa was analyzed for its extracts, revealing significant cytotoxicity in acetone and methanol against specific cancer cell lines (MCF-7, HT-29, HeLa) while showing lower toxicity to healthy cells (PDF fibroblasts).
- Three new secondary metabolites were isolated, with two exhibiting notable cytotoxic effects against MCF-7 and HT-29, highlighting the potential of Sarcosphaera crassa as a source of natural medicinal compounds.
Design of Amine-Containing Nanoporous Materials for Postcombustion CO Capture from Engineering Perspectives.
Acc Chem Res
November 2023
Department of Chemical and Biomolecular Engineering (BK21 Four), Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea.
ConspectusCarbon dioxide (CO) capture and storage (CCS) is a means to enable the continued use of fossil fuels in the short term. In particular, postcombustion CO capture has attracted considerable attention because it can be retrofitted into existing power plants and industrial plants. Among various CO capture technologies, the absorption of CO using aqueous amines has been industrially employed for decades.
View Article and Find Full Text PDF11-Step Total Synthesis of Teleocidins B-1-B-4.
J Am Chem Soc
January 2019
Department of Chemistry , The Scripps Research Institute, 10550 North Torrey Pines Road , La Jolla , California 92037 , United States.
A unified and modular approach to the teleocidin B family of natural products is presented that proceeds in 11 steps and features an array of interesting strategies and methods. Indolactam V, the known biosynthetic precursor to this family, was accessed through electrochemical amination, Cu-mediated aziridine opening, and a remarkable base-induced macrolactamization. Guided by a desire to minimize concession steps, the tactical combination of C-H borylation and a Sigman-Heck transform enabled the convergent, stereocontrolled synthesis of the teleocidins.
View Article and Find Full Text PDFMono- and Di-Alkylation Processes of DNA Bases by Nitrogen Mustard Mechlorethamine.
Chemphyschem
December 2017
Departamento de Química Orgánica I/ Kimika Organikoa I Saila, Facultad de Química/ Kimika Fakultatea, Universidad del País Vasco, Euskal Herriko Unibertsitatea UPV/EHU and Donostia International Physics Center (DIPC) and Centro de Innovación en Química Avanzada (ORFEO-CINQA), P. K. 1072, 20018, San Sebastián-Donostia, Spain.
The reactivity of nitrogen mustard mechlorethamine (mec) with purine bases towards formation of mono- (G-mec and A-mec) and dialkylated (AA-mec, GG-mec and AG-mec) adducts has been studied using density functional theory (DFT). To gain a complete overview of DNA-alkylation processes, direct chloride substitution and formation through activated aziridinium species were considered as possible reaction paths for adduct formation. Our results confirm that DNA alkylation by mec occurs via aziridine intermediates instead of direct substitution.
View Article and Find Full Text PDFSynthesis and characterization of oligonucleotides containing a nitrogen mustard formamidopyrimidine monoadduct of deoxyguanosine.
Chem Res Toxicol
September 2014
Departments of Chemistry and Biochemistry, Center in Molecular Toxicology, and Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee 37235, United States.
N(5)-Substituted formamidopyrimidine adducts have been observed from the reaction of dGuo or DNA with aziridine containing electrophiles, including nitrogen mustards. However, the role of substituted Fapy-dGuo adducts in the biological response to nitrogen mustards and related species has not been extensively explored. We have developed chemistry for the site-specific synthesis of oligonucleotides containing an N(5)-nitrogen mustard Fapy-dGuo using the phosphoramidite approach.
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