AI Article Synopsis
- The study describes the synthesis of 12 N6-(n-alkylureido)purine ribonucleosides with various alkyl chain lengths (1-10, 16, and 18 carbons) and three corresponding 5'-phosphates (4, 9, and 10 carbons).
- The ribonucleosides were made by reacting a specific ribonucleoside compound with n-alkylamine in heated pyridine, while the 5'-nucleotides were synthesized through phosphorylation techniques.
- Some of the synthesized compounds, particularly those with octyl, nonyl, and decyl chains, exhibited significant antiproliferative effects against L-1210 cancer cells in lab cultures
Article Abstract
Syntheses and biological activities of 12 N6-(n-alkylureido)purine ribonucleosides (alkyl chain length of 1--10, 16, and 18 carbons) and three N6-(n-alkylureido)purine ribonucleoside 5'-phosphates (chain length of 4, 9, and 10 carbons) are described. The N6-(n-alkylureido)purine ribonucleosides were prepared by a reaction of (2',3',5'-tri-O-acetyl-beta-D-ribofuranosyl)-9H-purine-6-carbamate and n-alkylamine in refluxing pyridine. The 5'-nucleotides were prepared by direct phosphorylation of the corresponding ribonucleoside with phosphorus oxychloride and triethyl phosphate. Some N6-(n-alkylureido)purine ribonucleosides (n-octyl, n-nonyl, and n-decyl) and their nucleotides showed a marked antiproliferative activity against L-1210 cells in culture.
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| http://dx.doi.org/10.1002/jps.2600670439 | DOI Listing |
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